Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

PRKG1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

PRKG1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1ZXA,3OCP,3OD0,3OGJ,4KU7,4KU8,4QX5,4QXK,4R4L,4R4M,4Z07

Identifiers
AliasesPRKG1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I, PKG1, protein kinase cGMP-dependent 1
External IDsOMIM:176894;MGI:108174;HomoloGene:55964;GeneCards:PRKG1;OMA:PRKG1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PRKG1
Genomic location for PRKG1
Band10q11.23-q21.1Start50,990,888bp[1]
End52,298,423bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for PRKG1
Genomic location for PRKG1
Band19|19 C1Start30,541,889bp[2]
End31,742,433bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • saphenous vein

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • Descending thoracic aorta

  • ascending aorta

  • Skeletal muscle tissue of rectus abdominis

  • right coronary artery

  • popliteal artery

  • urethra

  • tibial arteries
Top expressed in
  • spermatid

  • lumbar spinal ganglion

  • epithelium of lens

  • trigeminal ganglion

  • soleus muscle

  • sternocleidomastoid muscle

  • digastric muscle

  • temporal muscle

  • intercostal muscle

  • zygote
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5592

19091

Ensembl

ENSG00000185532

ENSMUSG00000052920

UniProt

Q13976

P0C605

RefSeq (mRNA)

NM_001098512
NM_006258
NM_001374781
NM_001374782

NM_001013833
NM_011160

RefSeq (protein)

NP_001091982
NP_006249
NP_001361710
NP_001361711

NP_001013855
NP_035290

Location (UCSC)Chr 10: 50.99 – 52.3 MbChr 19: 30.54 – 31.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

cGMP-dependent protein kinase 1, alpha isozyme is anenzyme that in humans is encoded by thePRKG1gene.[5][6][7]

Interactions

[edit]

PRKG1 has been shown tointeract with:

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000185532Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000052920Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat".FEBS Letters.255 (2):321–9.doi:10.1016/0014-5793(89)81114-7.PMID 2792381.S2CID 83233954.
  6. ^Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10".Cytogenetics and Cell Genetics.59 (4):270–3.doi:10.1159/000133267.PMID 1544322.
  7. ^"Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I".
  8. ^Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB (Aug 2002)."cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I".The Journal of Biological Chemistry.277 (35):32003–14.doi:10.1074/jbc.M112332200.PMID 12082086.
  9. ^abSchlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta".Nature.404 (6774):197–201.Bibcode:2000Natur.404..197S.doi:10.1038/35004606.PMID 10724174.S2CID 205004996.
  10. ^Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (Jun 2001)."Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta".The Journal of Biological Chemistry.276 (26):24153–9.doi:10.1074/jbc.M101530200.PMID 11309393.
  11. ^Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G (Dec 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure".Nature Medicine.9 (12):1506–12.doi:10.1038/nm958.PMID 14608379.S2CID 20331752.
  12. ^Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999)."A novel interaction of cGMP-dependent protein kinase I with troponin T".The Journal of Biological Chemistry.274 (52):37429–34.doi:10.1074/jbc.274.52.37429.PMID 10601315.

Further reading

[edit]
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


Stub icon

This article on agene on humanchromosome 10 is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=PRKG1&oldid=1195569437"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp