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PRIM2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
PRIM2
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

3L9Q,3Q36,4BPU,4BPW,4BPX,4RR2,5F0Q,5EXR,5F0S

Identifiers
AliasesPRIM2, PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2
External IDsOMIM:176636;MGI:97758;HomoloGene:731;GeneCards:PRIM2;OMA:PRIM2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PRIM2
Genomic location for PRIM2
Band6p11.2Start57,314,805bp[1]
End57,646,850bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PRIM2
Genomic location for PRIM2
Band1 12.7 cM|1 BStart33,492,891bp[2]
End33,708,876bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • gonad

  • ganglionic eminence

  • Achilles tendon

  • ventricular zone

  • testicle

  • oocyte

  • epithelium of colon

  • stromal cell of endometrium

  • rectum
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • secondary oocyte

  • genital tubercle

  • maxillary prominence

  • primary oocyte

  • mandibular prominence

  • medial ganglionic eminence

  • tail of embryo

  • cumulus cell

  • spermatocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5558

19076

Ensembl

ENSG00000146143

ENSMUSG00000026134

UniProt

P49643

P33610

RefSeq (mRNA)

NM_000947
NM_001282487
NM_001282488

NM_008922

RefSeq (protein)

NP_000938
NP_001269416
NP_001269417

NP_032948

Location (UCSC)Chr 6: 57.31 – 57.65 MbChr 1: 33.49 – 33.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA primase large subunit in humans is encoded by thePRIM2gene and is part of theenzymeDNA polymerase alpha.[5][6]

The replication of DNA ineukaryotic cells is carried out by a complex chromosomal replication apparatus, in whichDNA polymerase alpha andprimase are two key enzymatic components. Primase, which is aheterodimer of a small subunit and a large subunit, synthesizes small RNA primers for theOkazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000146143 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000026134 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12".Genomics.28 (2):350–3.doi:10.1006/geno.1995.1155.PMID 8530050.
  6. ^ab"Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa".

Further reading

[edit]

External links

[edit]
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA primase large subunit (PRIM2)


Initiation
Prokaryotic
(initiation)
Eukaryotic
(preparation in
G1 phase)
Both
Replication
Prokaryotic
(elongation)
Eukaryotic
(synthesis in
S phase)
Both
Termination
Stub icon

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