Serine/threonine-protein phosphatase PP1-beta catalytic subunit is anenzyme that in humans is encoded by thePPP1CBgene.[5]
The protein encoded by this gene is one of the three catalytic subunits ofprotein phosphatase 1 (PP1). PP1 is aserine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such ascell division,glycogen metabolism, muscle contractility,protein synthesis, andHIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Barker HM, Brewis ND, Street AJ, Spurr NK, Cohen PT (March 1994). "Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB)".Biochim Biophys Acta.1220 (2):212–8.doi:10.1016/0167-4889(94)90138-4.PMID8312365.
^Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (April 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1".Biochemistry.38 (14):4365–73.doi:10.1021/bi982900m.ISSN0006-2960.PMID10194355.
Fujioka M, Takahashi N, Odai H, et al. (1998). "A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping".Genomics.49 (1):59–68.doi:10.1006/geno.1998.5222.PMID9570949.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides".Nat. Biotechnol.21 (5):566–9.doi:10.1038/nbt810.PMID12665801.S2CID23783563.
Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes".J. Neurovirol.9 (3):358–71.doi:10.1080/13550280390201119.PMID12775419.S2CID22016092.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".Nat. Cell Biol.6 (2):97–105.doi:10.1038/ncb1086.PMID14743216.S2CID11683986.
