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PPARGC1B

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

PPARGC1B

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3SP6

Identifiers

Aliases

PPARGC1B, ERRL1, PERC, PGC-1(beta), PGC1B, PPARG coactivator 1 beta

External IDs

OMIM:608886;MGI:2444934;HomoloGene:15776;GeneCards:PPARGC1B;OMA:PPARGC1B - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q32	Start	149,730,298bp^[1]
Band	5q32	End	149,855,022bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 E1	Start	61,431,207bp^[2]
Band	18\|18 E1	End	61,533,502bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

secondary oocyte

germinal epithelium

jejunal mucosa

duodenum

testicle

Brodmann area 23

gonad

apex of heart

monocyte

Top expressed in

right ventricle

brown adipose tissue

ciliary body

cerebellar vermis

epithelium of stomach

lobe of cerebellum

left colon

crypt of lieberkuhn of small intestine

olfactory tubercle

pyloric antrum

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transcription coregulator activity AF-2 domain binding nuclear receptor coactivator activity RNA binding nucleic acid binding transcription factor binding estrogen receptor binding
Cellular component	mediator complex mitochondrion nucleus nucleoplasm
Biological process	mitochondrial transcription regulation of transcription, DNA-templated ossification actin filament organization positive regulation of osteoclast differentiation positive regulation of DNA-binding transcription factor activity response to glucocorticoid bone trabecula formation positive regulation of bone resorption transcription, DNA-templated positive regulation of transcription, DNA-templated cellular response to reactive oxygen species positive regulation of alkaline phosphatase activity response to cAMP positive regulation of phosphorylation negative regulation of transcription, DNA-templated intracellular estrogen receptor signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of cold-induced thermogenesis regulation of nucleic acid-templated transcription
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


133522


170826

Ensembl


ENSG00000155846


ENSMUSG00000033871

UniProt


Q86YN6


Q8VHJ7

RefSeq (mRNA)


NM_001172698 NM_001172699 NM_133263


NM_133249 NM_001364996

RefSeq (protein)


NP_001166169 NP_001166170 NP_573570


NP_573512 NP_001351925

Location (UCSC)

Chr 5: 149.73 – 149.86 Mb

Chr 18: 61.43 – 61.53 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is aprotein that in humans is encoded by thePPARGC1Bgene.^[5]^[6]^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000155846 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000033871 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002)."Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus".Diabetologia.44 (12):2220–6.doi:10.1007/s001250100032.PMID 11793024.
^Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002)."The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha".J Biol Chem.277 (16):13918–25.doi:10.1074/jbc.M201134200.PMID 11854298.
^"Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta".

Handschin C, Spiegelman BM (2007)."Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism".Endocr. Rev.27 (7):728–35.doi:10.1210/er.2006-0037.PMID 17018837.
Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression".Genomics.62 (1):98–102.doi:10.1006/geno.1999.5977.PMID 10585775.
Knutti D, Kaul A, Kralli A (2000)."A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen".Mol. Cell. Biol.20 (7):2411–22.doi:10.1128/MCB.20.7.2411-2422.2000.PMC 85422.PMID 10713165.
Lin J, Puigserver P, Donovan J, et al. (2002)."Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor".J. Biol. Chem.277 (3):1645–8.doi:10.1074/jbc.C100631200.PMID 11733490.
Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians".Diabetologia.45 (4):602–3, author reply 604.doi:10.1007/s00125-002-0783-z.PMID 12032643.
Hara K, Tobe K, Okada T, et al. (2003)."A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes".Diabetologia.45 (5):740–3.doi:10.1007/s00125-002-0803-z.PMID 12107756.
Huss JM, Kopp RP, Kelly DP (2002)."Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha".J. Biol. Chem.277 (43):40265–74.doi:10.1074/jbc.M206324200.PMID 12181319.
Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma".Biochem. Biophys. Res. Commun.299 (5):872–9.doi:10.1016/S0006-291X(02)02753-5.PMID 12470660.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Shiraki T, Sakai N, Kanaya E, Jingami H (2003)."Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state".J. Biol. Chem.278 (13):11344–50.doi:10.1074/jbc.M212859200.PMID 12551939.
Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance".Biochem. Biophys. Res. Commun.301 (2):578–82.doi:10.1016/S0006-291X(03)00014-7.PMID 12565902.
Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003)."Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo".Biochem. J.373 (Pt 1):155–65.doi:10.1042/BJ20030200.PMC 1223480.PMID 12678921.
Patti ME, Butte AJ, Crunkhorn S, et al. (2003)."Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1".Proc. Natl. Acad. Sci. U.S.A.100 (14):8466–71.Bibcode:2003PNAS..100.8466P.doi:10.1073/pnas.1032913100.PMC 166252.PMID 12832613.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Ling C, Poulsen P, Carlsson E, et al. (2004)."Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins".J. Clin. Invest.114 (10):1518–26.doi:10.1172/JCI21889.PMC 525741.PMID 15546003.
Andersen G, Wegner L, Yanagisawa K, et al. (2006)."Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity".J. Med. Genet.42 (5):402–7.doi:10.1136/jmg.2004.026278.PMC 1736055.PMID 15863669.
Staiger H, Staiger K, Haas C, et al. (2005)."Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro".Diabetologia.48 (10):2115–8.doi:10.1007/s00125-005-1895-z.PMID 16132959.
Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006)."Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer".Carcinogenesis.27 (11):2201–8.doi:10.1093/carcin/bgl067.PMID 16704985.

External links

[edit]

PPARGC1B protein, human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
NURSA C21

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Transcription coregulators
Coactivators	ARA (54,55,70) BCAS3 CARM1 p300-CBP (EP300,CREBBP) CRTC (1,2,3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1,2) PPARGC (1A,1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1,2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif familyTRIM (24,28,33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF