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POU4F3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

POU4F3
Identifiers
AliasesPOU4F3, BRN3C, DFNA15, POU class 4 homeobox 3, DFNA42, DFNA52
External IDsOMIM:602460;MGI:102523;HomoloGene:2023;GeneCards:POU4F3;OMA:POU4F3 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for POU4F3
Genomic location for POU4F3
Band5q32Start146,338,839bp[1]
End146,341,728bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for POU4F3
Genomic location for POU4F3
Band18 B3|18 22.58 cMStart42,527,604bp[2]
End42,530,314bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • smooth muscle tissue

  • tibial arteries

  • islet of Langerhans

  • C1 segment
Top expressed in
  • lumbar spinal ganglion

  • organ of Corti

  • embryo

  • vestibular sensory epithelium

  • neural layer of retina

  • otolith organ

  • utricle

  • saccule

  • basal plate

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5459

18998

Ensembl

ENSG00000091010

ENSMUSG00000024497

UniProt

Q15319

Q63955

RefSeq (mRNA)

NM_002700

NM_138945

RefSeq (protein)

NP_002691

NP_620395

Location (UCSC)Chr 5: 146.34 – 146.34 MbChr 18: 42.53 – 42.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

POU domain, class 4, transcription factor 3 is aprotein that in humans is encoded by thePOU4F3gene.[5][6] It's a member ofBRN-3 group, also known asPOU family class 4.

Nomenclature

[edit]

DFNA15 refers to a type ofnonsyndromic deafness, withautosomal dominant inheritance.

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000091010Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000024497Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB (Apr 1998)."Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans".Science.279 (5358):1950–4.Bibcode:1998Sci...279.1950V.doi:10.1126/science.279.5358.1950.PMID 9506947.S2CID 25291858.
  6. ^"Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3".

Further reading

[edit]
In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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