Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

POU4F2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
POU4F2
Identifiers
AliasesPOU4F2, BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDsOMIM:113725;MGI:102524;HomoloGene:20959;GeneCards:POU4F2;OMA:POU4F2 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for POU4F2
Genomic location for POU4F2
Band4q31.22Start146,638,893bp[1]
End146,642,474bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • pons

  • pancreatic ductal cell

  • mucosa of ileum

  • sensory ganglion

  • trigeminal ganglion

  • ventral tegmental area

  • medulla oblongata

  • pars compacta

  • superior vestibular nucleus
Top expressed in
  • lumbar spinal ganglion

  • trigeminal ganglion

  • superior colliculus

  • morula

  • otolith organ

  • inferior colliculi

  • utricle

  • ganglion cell layer

  • embryo

  • pontine nuclei
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5458

18997

Ensembl

ENSG00000151615

ENSMUSG00000031688

UniProt

Q12837

Q63934

RefSeq (mRNA)

NM_004575

NM_138944

RefSeq (protein)

NP_004566

NP_620394

Location (UCSC)Chr 4: 146.64 – 146.64 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

POU domain, class 4, transcription factor 2 is aprotein that in humans is encoded by thePOU4F2gene.[4][5]

Function

[edit]

POU4F2 is a member of thePOU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. Aclass IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation ofganglion cells where it may play a role in determining or maintaining the identities of a small subset ofvisual systemneurons.[supplied by OMIM][5]

Interactions

[edit]

POU4F2 has been shown tointeract withEstrogen receptor alpha.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000151615Ensembl, May 2017
  2. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^Ring CJ, Latchman DS (Jun 1993)."The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain".Nucleic Acids Research.21 (12): 2946.doi:10.1093/nar/21.12.2946.PMC 309696.PMID 8332509.
  5. ^ab"Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".
  6. ^Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998)."POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element".Molecular and Cellular Biology.18 (2):1029–41.doi:10.1128/mcb.18.2.1029.PMC 108815.PMID 9448000.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


Stub icon

This article on agene on humanchromosome 4 is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=POU4F2&oldid=1300847086"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp