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Razpipadon

From Wikipedia, the free encyclopedia
(Redirected fromPF 6669571)
Chemical compound

Pharmaceutical compound
Razpipadon
Clinical data
Other namesCVL-871; CVL871; PF-06669571; PF06669571; PF-6669571; PF6669571; PW-0464; PW0464
Routes of
administration
Oral[1]
Drug classDopamine receptor agonist;DopamineD1 andD5 receptoragonist
Identifiers
  • 6-[4-[3-(difluoromethoxy)pyridin-2-yl]oxy-2-methylphenyl]-1,5-dimethylpyrimidine-2,4-dione
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC19H17F2N3O4
Molar mass389.359 g·mol−1
3D model (JSmol)
  • CC1=C(C=CC(=C1)OC2=C(C=CC=N2)OC(F)F)C3=C(C(=O)NC(=O)N3C)C
  • InChI=1S/C19H17F2N3O4/c1-10-9-12(27-17-14(28-18(20)21)5-4-8-22-17)6-7-13(10)15-11(2)16(25)23-19(26)24(15)3/h4-9,18H,1-3H3,(H,23,25,26)
  • Key:ZXIPVZWZRQCIRW-UHFFFAOYSA-N

Razpipadon (developmental codesCVL-871,PF-06669571, andPW-0464) is adopamine receptor agonist which is under development for the treatment ofdementia-related apathy.[1][2][3][4] It is takenorally.[1]

Razpipadon acts as aselectivepartial agonist of thedopamineD1 andD5 receptors.[1][2][5]

The drug was originated byPfizer and is under development byCerevel Therapeutics.[1] As of April 2022, razpipadon is inphase 2clinical trials for dementia-related apathy.[1]

See also

[edit]

References

[edit]
  1. ^abcdef"CVL 871 - AdisInsight".
  2. ^abHatzipantelis CJ, Langiu M, Vandekolk TH, Pierce TL, Nithianantharajah J, Stewart GD, Langmead CJ (December 2020)."Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia".ACS Pharmacol Transl Sci.3 (6):1042–1062.doi:10.1021/acsptsci.0c00117.PMC 7737210.PMID 33344888.
  3. ^Wang HJ, Chinna-Meyyappan A, Feldman OJ, Lanctôt KL (June 2024). "Emerging therapies for treatment of agitation, psychosis, or apathy in Alzheimer's disease".Expert Opin Emerg Drugs:1–15.doi:10.1080/14728214.2024.2363215.PMID 38822731.
  4. ^Dolphin H, Dyer AH, McHale C, O'Dowd S, Kennelly SP (July 2023)."An Update on Apathy in Alzheimer's Disease".Geriatrics.8 (4): 75.doi:10.3390/geriatrics8040075.PMC 10366907.PMID 37489323.
  5. ^"CVL-871 - Cerevel Therapeutics". 2 January 2020.

External links

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D1-like
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Antagonists
D2-like
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