PEAQX

Clinical data
Other names	PEAQX, NVP-AAM077
Identifiers
IUPAC name ({[(1S)-1-(4-bromophenyl)ethyl]amino}-(2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methyl)phosphonic acid
CAS Number	459836-30-7
PubChemCID	9868551
ChemSpider	8044242 N
UNII	LE8K7M4APN
ChEMBL	ChEMBL273636
Chemical and physical data
Formula	C17H17BrN3O5P
Molar mass	454.217 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H](C1=CC=C(C=C1)Br)NC(C2=C3C(=CC=C2)N=C(C(=N3)O)O)P(=O)(O)O
InChI InChI=1S/C17H17BrN3O5P/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26)/t9-,17?/m0/s1 N Key:XXZGNAZRWCBSBK-WFVOFKTRSA-N N
NY (what is this?)  (verify)

PEAQX is a competitiveantagonist at theNMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies^[1] of the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potentanticonvulsant in animal tests.^[2]

• NMDA receptor antagonists
• 4-Bromophenyl compounds
• Quinoxalines
• Lactams
• Phosphonic acids

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