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PD-0299685

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(Redirected fromPD-299,685)

Pharmaceutical compound
PD-0299685
Clinical data
Other namesPD-0299685; PD-299685; PD0299685; PD299685; PD-299,685
Routes of
administration
Oral[1]
Drug classGabapentinoid
ATC code
  • None
Identifiers
  • (3S,5R)-3-(aminomethyl)-5-methyloctanoic acid
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC10H21NO2
Molar mass187.283 g·mol−1
3D model (JSmol)
  • CCC[C@@H](C)C[C@@H](CC(=O)O)CN
  • InChI=1S/C10H21NO2/c1-3-4-8(2)5-9(7-11)6-10(12)13/h8-9H,3-7,11H2,1-2H3,(H,12,13)/t8-,9+/m1/s1
  • Key:KKXFMWXZXDUYBF-BDAKNGLRSA-N

PD-0299685 is agabapentinoid (α2δ subunit-containingvoltage-gated calcium channelblocker) which was under development for the treatment ofinsomnia andvasomotor symptoms (hot flashes) related tomenopause as well asinterstitial cystitis.[1][2][3] It is takenorally.[1] PD-0299685 was under development byPfizer.[1] It reachedphase 2clinical trials prior to the discontinuation of its development.[1]

See also

[edit]

References

[edit]
  1. ^abcde"PD 0299685".AdisInsight. 5 November 2023. Retrieved3 October 2025.
  2. ^Lewis V (November 2009). "Undertreatment of menopausal symptoms and novel options for comprehensive management".Current Medical Research and Opinion.25 (11):2689–2698.doi:10.1185/03007990903240519.PMID 19775194.
  3. ^Nickel JC, Crossland A, Davis E, Haab F, Mills IW, Rovner E, et al. (September 2012). "Investigation of a Ca2+ channel α2δ ligand for the treatment of interstitial cystitis: results of a randomized, double-blind, placebo controlled phase II trial".The Journal of Urology.188 (3):817–823.doi:10.1016/j.juro.2012.05.010.PMID 22818144.
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
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