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P2RY2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

P2RY2

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1Z8E

Identifiers

Aliases

P2RY2, HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R, purinergic receptor P2Y2

External IDs

OMIM:600041;MGI:105107;HomoloGene:1927;GeneCards:P2RY2;OMA:P2RY2 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.4	Start	73,218,281bp^[1]
Band	11q13.4	End	73,242,427bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 E2	Start	100,645,775bp^[2]
Band	7\|7 E2	End	100,662,073bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

muscle of thigh

gastrocnemius muscle

Skeletal muscle tissue of rectus abdominis

mucosa of esophagus

vastus lateralis muscle

biceps brachii

Skeletal muscle tissue of biceps brachii

deltoid muscle

gingival epithelium

triceps brachii muscle

Top expressed in

muscle of thigh

extensor digitorum longus muscle

corneal stroma

plantaris muscle

granulocyte

soleus muscle

interventricular septum

skeletal muscle tissue

digastric muscle

thoracic diaphragm

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity G protein-coupled purinergic nucleotide receptor activity signal transducer activity signaling receptor activity
Cellular component	integral component of membrane membrane integral component of plasma membrane plasma membrane
Biological process	G protein-coupled purinergic nucleotide receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway cellular ion homeostasis positive regulation of mucus secretion signal transduction blood vessel diameter maintenance G protein-coupled receptor signaling pathway cellular response to ATP
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


5029


18442

Ensembl


ENSG00000175591


ENSMUSG00000032860

UniProt


P41231


P35383

RefSeq (mRNA)


NM_002564 NM_176071 NM_176072


NM_008773 NM_001302346 NM_001302347

RefSeq (protein)


NP_002555 NP_788085 NP_788086


NP_001289275 NP_001289276 NP_032799

Location (UCSC)

Chr 11: 73.22 – 73.24 Mb

Chr 7: 100.65 – 100.66 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

P2Y purinoceptor 2 is aprotein that in humans is encoded by theP2RY2gene.^[5]^[6]

The product of this gene, P2Y₂ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000175591 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000032860 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994)."Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy".Proc Natl Acad Sci USA.91 (8):3275–9.Bibcode:1994PNAS...91.3275P.doi:10.1073/pnas.91.8.3275.PMC 43559.PMID 8159738.
^Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family".Genomics.44 (1):127–30.doi:10.1006/geno.1997.4841.PMID 9286708.
^"Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2".

External links

[edit]

"P2Y Receptors: P2Y₂".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-09.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

Purine receptor modulators

Receptor
(ligands)

P0 (adenine)

Agonists:8-Aminoadenine
Adenine

P1
(adenosine)

P2
(nucleotide)

P2X
(ATPTooltip Adenosine triphosphate)

P2Y

Transporter
(blockers)

CNTsTooltip Concentrative nucleoside transporters	6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone
ENTsTooltip Equilibrative nucleoside transporters	Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline
PMATTooltip Plasma membrane monoamine transporter	Decynium-22

Enzyme
(inhibitors)

XOTooltip Xanthine oxidase	Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat
Others	Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others