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P2RX6

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

P2RX6

Identifiers

Aliases

P2RX6, P2RXL1, P2X6, P2XM, purinergic receptor P2X 6

External IDs

OMIM:608077;MGI:1337113;HomoloGene:3975;GeneCards:P2RX6;OMA:P2RX6 - orthologs

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q11.21	Start	21,009,808bp^[1]
Band	22q11.21	End	21,028,013bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 A3	Start	17,379,749bp^[2]
Band	16\|16 A3	End	17,395,664bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastrocnemius muscle

muscle of thigh

right frontal lobe

right uterine tube

Brodmann area 9

apex of heart

spleen

anterior cingulate cortex

anterior pituitary

prefrontal cortex

Top expressed in

facial motor nucleus

muscle of thigh

skeletal muscle tissue

soleus muscle

quadriceps femoris muscle

morula

medial head of gastrocnemius muscle

temporal muscle

masseter muscle

anterior horn of spinal cord

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	channel activity purinergic nucleotide receptor activity extracellularly ATP-gated cation channel activity ion channel activity identical protein binding ATP binding transmembrane signaling receptor activity ATP-gated ion channel activity
Cellular component	cytoplasm integral component of membrane membrane integral component of nuclear inner membrane integral component of plasma membrane cell junction plasma membrane postsynapse postsynaptic density soma dendritic spine parallel fiber to Purkinje cell synapse glutamatergic synapse integral component of postsynaptic specialization membrane
Biological process	response to ATP muscle contraction ion transport cation transmembrane transport protein homooligomerization signal transduction blood coagulation purinergic nucleotide receptor signaling pathway excitatory postsynaptic potential protein heterooligomerization cation transport ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9127


18440

Ensembl


ENSG00000099957


ENSMUSG00000022758

UniProt


O15547


O54803

RefSeq (mRNA)

NM_001159554 NM_005446 NM_001349874 NM_001349875 NM_001349876
NM_001394691 NM_001394692 NM_001394693 NM_001394694 NM_001394695 NM_001394696 NM_001394697


NM_001159561 NM_011028

RefSeq (protein)


NP_001153026 NP_005437 NP_001336803 NP_001336804 NP_001336805


NP_001153033 NP_035158

Location (UCSC)

Chr 22: 21.01 – 21.03 Mb

Chr 16: 17.38 – 17.4 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

P2X purinoceptor 6 is aprotein that in humans is encoded by theP2RX6gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.^[8]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000099957 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000022758 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53".Cancer Res.57 (15):3281–7.PMID 9242461.
^Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999)."The DNA sequence of human chromosome 22".Nature.402 (6761):489–95.Bibcode:1999Natur.402..489D.doi:10.1038/990031.PMID 10591208.
^Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996)."Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels".J Neurosci.16 (8):2495–507.doi:10.1523/JNEUROSCI.16-08-02495.1996.PMC 6578782.PMID 8786426.
^^a ^b"Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor".

External links

[edit]

P2RXL1+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Ion channel,cell surface receptor:ligand-gated ion channels

Cys-loop receptors

5-HT/serotonin	5-HT₃ A B C D E
GABA	GABA_A α₁ α₂ α₃ α₄ α₅ α₆ β₁ β₂ β₃ γ₁ γ₂ γ₃ δ ε π θ GABA_A-ρ ρ₁ ρ₂ ρ₃
Glycine	α₁ α₂ α₃ α₄ β
Nicotinic acetylcholine	monomers:α1 α2 α3 α4 α5 α6 α7 α9 α10 β1 β2 β3 β4 δ ε pentamers:(α3)₂(β4)₃ (α4)₂(β2)₃ (α7)₅ (α1)₂(β4)₃ - Ganglion type (α1)₂β1δε - Muscle type
Zinc	Zinc-activated

Ionotropic glutamates

Ligand-gated only	AMPA (1 2 3 4) Kainate 1 2 3 4 5
Voltage- and ligand-gated	NMDA 1 2A 2B 2C 2D 3A 3B L1A L1B
‘Orphan’	GluD δ₁ δ₂

ATP-gated channels

Purinergic receptors	P2X 1 2 3 4 5 6 7

Purine receptor modulators

Receptor
(ligands)

P0 (adenine)

Agonists:8-Aminoadenine
Adenine

P1
(adenosine)

P2
(nucleotide)

P2X
(ATPTooltip Adenosine triphosphate)

P2Y

Transporter
(blockers)

CNTsTooltip Concentrative nucleoside transporters	6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone
ENTsTooltip Equilibrative nucleoside transporters	Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline
PMATTooltip Plasma membrane monoamine transporter	Decynium-22

Enzyme
(inhibitors)

XOTooltip Xanthine oxidase	Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat
Others	Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others