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Ozolinone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Ozolinone
Skeletal formula of ozolinone
Space-filling model of oxolinone
Clinical data
Routes of
administration
Oral
ATC code
  • None
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • (2Z)-2-(3-methyl-4-oxo-5-piperidin-1-yl-1,3-thiazolidin-2-ylidene)acetic acid
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
ECHA InfoCard100.054.876Edit this at Wikidata
Chemical and physical data
FormulaC11H16N2O3S
Molar mass256.32 g·mol−1
3D model (JSmol)
  • O=C(O)/C=C1/N(C)C(=O)C(S1)N2CCCCC2

Ozolinone is aloop diuretic which was never marketed.[1][2][3]

It is anactive metabolite ofetozoline.[2]

See also

[edit]

References

[edit]
  1. ^Dictionary of organic compounds. London: Chapman & Hall. 1996.ISBN 0-412-54090-8.
  2. ^abGreven J, Heidenreich O (October 1978). "Effects of ozolinone, a diuretic active metabolite of etozoline, on renal function. I. Clearance studies in dogs".Naunyn-Schmiedeberg's Archives of Pharmacology.304 (3):283–7.doi:10.1007/bf00507970.PMID 714186.S2CID 20878253.
  3. ^Greven J, Beckers M, Defrain W, Meywald K, Heidenreich O (March 1980). "Studies with the optically active isomers of the new diuretic drug ozolinone. II. Inhibition by d-ozolinone of furosemide-induced diuresis".Pflügers Archiv: European Journal of Physiology.384 (1):61–4.doi:10.1007/bf00589515.PMID 7189867.S2CID 13461213.
Sulfonamides
(andetacrynic acid)
CA inhibitors (atPT)
Loop (Na-K-Cl atAL)
Thiazides (Na-Cl atDCT,
Calcium-sparing)
Thiazide-likes (primarilyDCT)
Potassium-sparing (atCD)
ESC blockers
Aldosterone antagonists
Osmotic diuretics (PT,DL)
Vasopressin receptor inhibitors
(DCT andCD)
Other
Combination products


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