Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Oxipurinol

From Wikipedia, the free encyclopedia
Oxipurinol
Names
Preferred IUPAC name
1H-pyrazolo[3,4-d]pyrimidine-4,6(2H,5H)-dione
Other names
2,5-Dihydro-1H-pyrazolo[3,4-d]pyrimidine-4,6-dione
Alloxanthine
Identifiers
3D model (JSmol)
139956
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard100.017.792Edit this at Wikidata
EC Number
  • 219-570-9
KEGG
MeSHOxypurinol
UNII
  • InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
    Key: HXNFUBHNUDHIGC-UHFFFAOYSA-N
  • O=C1NC(=O)C2=CNNC2=N1
Properties
C5H4N4O2
Molar mass152.11086
Appearancewhite crystals
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Oxipurinol (INN, oroxypurinolUSAN) is aninhibitor ofxanthine oxidase.[1] It is anactive metabolite ofallopurinol and it is cleared renally.[2] In cases of renal disease, this metabolite will accumulate to toxic levels. By inhibiting xanthine oxidase, it reducesuric acid production. High serum uric acid levels may result ingout,kidney stones, and other medical conditions.

References

[edit]
  1. ^Stocker, Sophie L; McLachlan, Andrew J; Savic, Radojka M; Kirkpatrick, Carl M; Graham, Garry G; Williams, Kenneth M; Day, Richard O (2012)."The pharmacokinetics of oxypurinol in people with gout".British Journal of Clinical Pharmacology.74 (3):477–489.doi:10.1111/j.1365-2125.2012.04207.x.PMC 3477349.PMID 22300439.
  2. ^Elion, Gertrude B; Yü, Ts'ai-Fan; Gutman, Alexander B; Hitchings, George H (1968). "Renal clearance of oxipurinol, the chief metabolite of allopurinol".The American Journal of Medicine.45 (1):69–77.doi:10.1016/0002-9343(68)90008-9.PMID 5658870.


Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others
Authority control databasesEdit this at Wikidata


Stub icon

This article about aheterocyclic compound is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Oxipurinol&oldid=1014325281"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp