Oxaprotiline is aracemic compound composed of twoisomers,R(−)- orlevo- oxaprotiline (levoprotiline;CGP-12,103-A), andS(+)- or dextro- oxaprotiline (dextroprotiline;CGP-12,104-A). Both enantiomers are active, with the levo- form acting as anantihistamine and the dextro- form having an additional pharmacology (seeabove), but with both unexpectedly still retaining antidepressant effects.[6]
^Giedke H, Gaertner H, Breyer-Pfaff U, Rein W, Axmann D (1986). "Amitriptyline and oxaprotiline in the treatment of hospitalized depressive patients. Clinical aspects, psychophysiology, and drug plasma levels".European Archives of Psychiatry and Neurological Sciences.235 (6):329–338.doi:10.1007/bf00381001.PMID3527706.S2CID24152419.
^abReimann IW, Firkusny L, Antonin KH, Bieck PR (1993). "Oxaprotiline: enantioselective noradrenaline uptake inhibition indicated by intravenous amine pressor tests but not alpha 2-adrenoceptor binding to intact platelets in man".European Journal of Clinical Pharmacology.44 (1):93–5.doi:10.1007/BF00315288.PMID8382162.S2CID22691825.
^abNoguchi S, Inukai T, Kuno T, Tanaka C (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking".Physiology & Behavior.51 (6):1123–7.doi:10.1016/0031-9384(92)90297-F.PMID1353628.S2CID29562845.
^Noguchi S, Fukuda Y, Inukai T (May 1992). "Possible contributory role of the central histaminergic system in the forced swimming model".Arzneimittel-Forschung.42 (5):611–3.PMID1530672.
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