Gross pathology of an ovarian carcinoma.Benign, borderline, or malignant neoplasm involving the ovary
Ovarian tumors , or ovarian neoplasms, aretumors in theovary .[ 1] Not all areovarian cancer .[ 1] They consist of mainly solid tissue, whileovarian cysts contain fluid.[ 2]
In 2020, theWorld Health Organization (WHO) divided ovarian tumours as 90% epithelial, 3% germ cell, and 2% sex cord-stromal types.[ 3]
Histopathologic classification [ edit ] Ovarian tumors byincidence and risk ofovarian cancer [ 4] Tumor of the ovary vary remarkably as they may arise from any of the 3 cell types of the normal ovary.
Ovarian tumors are classified according to thehistology of the tumor, obtained in apathology report. Histology dictates many aspects of clinical treatment, management, andprognosis .
The most common forms are:
Type Subtype Relative incidence[ 5] Percent malignant[ 5] Comments Micrograph Germ cell tumor Mature cysticteratoma 46.0% 0.17% to 2%[ 6] Cystic, with elements of all 3germ layers (endoderm ,mesoderm andectoderm ).[ 7] Hair follicles. Immature teratoma 2.5% 100% Ateratoma that containsanaplastic immature elements, and is often synonymous withmalignant teratoma .[ 8] Other germ cell tumors 3.0% Others mainly includedysgerminoma ,yolk sac tumor ,struma ovarii andsquamous cell carcinoma arising from a dermoid cyst, and malignant mixed germ cell tumor.[ 5] Surface epithelial-stromal tumor Serous tumor 25% 18.5% Benign serous tumors of the right ovarian cyst are thinwalled unilocular cysts that are lined by ciliated pseudostratified cuboidal or columnar epithelium.[ 9] Mucinous tumor 15% 8.8% Benign mucinous tumors of the ovary consist of simple, nonstratified columnar epithelium with basally-located hyperchromatic nuclei and resemble gastric foveolar epithelium.[ 9] Endometrioid tumor 1% Almost 100% Tubular glands, resembling endometrium.[ 10] Other surface-epithelial tumors 1.5% Others include mainly malignant mixedMüllerian tumor ,Brenner tumor and mixed epithelial tumor.[ 5] Brenner tumor .Sex cord-stromal tumor Ovarian fibroma 1.5% 0% Spindle-shaped fibroblastic cells and abundant collagen.[ 11] Adultgranulosa cell tumor 1% Almost 100% Small, bland, cuboidal to polygonal cells in various patterns.[ 12] Other sex cord-stromal tumors 1% Others include mainlyjuvenile granulosa cell tumor ,thecoma andsclerosing stromal tumor [ 5] Secondary/metastatic) tumor 2% 100% Usually frombreast cancer ,colon cancer ,endometrial cancer ,stomach cancer orcervical cancer .[ 13]
Mixed tumors contain elements of more than one of the above classes of tumor histology.
An 1882 article appearing inScientific American mentions the case of a patient atUniversity of Pennsylvania Hospital when Dr.William Goodell removed a 112 lbs tumor from a 31 year old patient, who weighted 75 lbs after removal from the tumor.[ 14]
^a b WHO Classification of Tumours Editorial Board, ed. (2020). "1. Tumours of the ovary: introduction".Female genital tumours: WHO Classification of Tumours . Vol. 4 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 32– 35.ISBN 978-92-832-4504-9 . ^ Euscher, Elizabeth D.; Hui, Jian-Jun (2021)."9. Ovarian epithelial neoplasia" . In Wei, Jian-Jun; Hui, Pei (eds.).Practical Gynecologic Pathology: Frequently Asked Questions . Switzerland: Springer. pp. 225– 262.ISBN 978-3-030-68608-6 . ^ De Leo, A; Santini, D; Ceccarelli, C; Santandrea, G; Palicelli, A; Acquaviva, G; Chiarucci, F; Rosini, F; Ravegnini, G; Pession, A; Turchetti, D; Zamagni, C; Perrone, AM; De Iaco, P; Tallini, G; de Biase, D (14 April 2021)."What Is New on Ovarian Carcinoma: Integrated Morphologic and Molecular Analysis Following the New 2020 World Health Organization Classification of Female Genital Tumors" .Diagnostics (Basel, Switzerland) .11 (4): 697.doi :10.3390/diagnostics11040697 .PMC 8070731 .PMID 33919741 . ^ -Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014)."Spectrum of ovarian tumors in a referral hospital in Nepal" .Journal of Pathology of Nepal .4 (7):539– 543.doi :10.3126/jpn.v4i7.10295 .ISSN 2091-0908 . - Minor adjustment for mature cystic teratomas (0.17 to 2% risk of ovarian cancer):Mandal, Shramana; Badhe, Bhawana A. (2012)."Malignant Transformation in a Mature Teratoma with Metastatic Deposits in the Omentum: A Case Report" .Case Reports in Pathology .2012 :1– 3.doi :10.1155/2012/568062 .ISSN 2090-6781 .PMC 3469088 .PMID 23082264 . ^a b c d e Unless otherwise specified in boxes, reference is:Vaidya, SA; Kc, S; Sharma, P; Vaidya, S (2014)."Spectrum of ovarian tumors in a referral hospital in Nepal" .Journal of Pathology of Nepal .4 (7):539– 543.doi :10.3126/jpn.v4i7.10295 .ISSN 2091-0908 . ^ Mandal, Shramana; Badhe, Bhawana A. (2012)."Malignant Transformation in a Mature Teratoma with Metastatic Deposits in the Omentum: A Case Report" .Case Reports in Pathology .2012 :1– 3.doi :10.1155/2012/568062 .ISSN 2090-6781 .PMC 3469088 .PMID 23082264 . ^ Hillary Rose Elwood."Skin nonmelanocytic tumor - Other tumors of skin - Benign (mature) cystic teratoma" .pathology Outlines . Topic Completed: 1 November 2016. Revised: 4 April 2019^ Sun, Hang; Ding, Hongxin; Wang, Jianjun; Zhang, Emma; Fang, Yihua; Li, Zhenhua; Yu, Xiao; Wang, Chongren; Zhao, Yifan; Chen, Kan; Wen, Siwan; Li, Liang; Shan, Shan; Hong, Liu; Chen, Face; Su, Pu (2019)."The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy" .BMC Cancer .19 (1): 408.doi :10.1186/s12885-019-5598-0 .ISSN 1471-2407 .PMC 6492338 .PMID 31039746 . ^a b Baradwan, Saeed; Alalyani, Haneen; Baradwan, Amira; Baradwan, Afnan; Al-Ghamdi, Maram; Alnemari, Jameel; Al-Jaroudi, Dania (2018)."Bilateral ovarian masses with different histopathology in each ovary" .Clinical Case Reports .6 (5):784– 787.doi :10.1002/ccr3.1466 .ISSN 2050-0904 .PMC 5930217 .PMID 29744056 . ^ Shahrzad Ehdaivand."Ovary tumor - Endometrioid tumors - General" .Pathology Outlines . Topic Completed: 1 December 2012. Revised: 6 March 2020^ Parwate, Nikhil Sadanand; Patel, Shilpa M.; Arora, Ruchi; Gupta, Monisha (2015)."Ovarian Fibroma: A Clinico-pathological Study of 23 Cases with Review of Literature" .The Journal of Obstetrics and Gynecology of India .66 (6):460– 465.doi :10.1007/s13224-015-0717-6 .ISSN 0971-9202 .PMC 5080219 .PMID 27821988 . ^ Shahrzad Ehdaivand."Ovary tumor - Sex cord stromal tumors - Granulosa cell tumor - adult" .Pathology Outlines . Topic Completed: 1 December 2012. Revised: 9 March 2020^ Lisa Lee-Jones, University of Wales College of Medicine (2003-12-01)."Ovarian tumours : an overview" .Atlas of Genetics and Cytogenetics in Oncology and Haematology . ^ Scientific American . Munn & Company. 1882-02-25. p. 114.