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Orosomucoid

From Wikipedia, the free encyclopedia
Acute phase protein found in plasma
orosomucoid 1
Identifiers
SymbolORM1
NCBI gene5004
HGNC8498
OMIM138600
RefSeqNM_000607
UniProtP02763
Other data
LocusChr. 9q31-qter
Search for
StructuresSwiss-model
DomainsInterPro
orosomucoid 2
Identifiers
SymbolORM2
NCBI gene5005
HGNC8499
OMIM138610
RefSeqNM_000608
UniProtP19652
Other data
LocusChr. 9q31-qter
Search for
StructuresSwiss-model
DomainsInterPro

Orosomucoid (ORM) oralpha-1-acid glycoprotein (α1AGp,[1]AGP orAAG) is anacute phase protein found inplasma. It is analpha-globulinglycoprotein and is modulated by twopolymorphic genes. It is synthesized primarily inhepatocytes and has a normal plasma concentration between 0.6–1.2 mg/mL (1–3% plasma protein).[2] Plasma levels are affected bypregnancy, burns, certain drugs, and certain diseases, particularlyHIV.[2]

The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of basic (positively charged) drugs (whereasalbumin carries acidic (negatively charged) and neutral drugs),steroids, andprotease inhibitors.[2][3] Aging causes a small decrease in plasma albumin levels; if anything, there is a small increase in alpha-1-acid glycoprotein. The effect of these changes on drug protein binding and drug delivery, however, appear to be minimal.[4] AGP shows a complex interaction withthyroid homeostasis: AGP in low concentrations was observed to stimulate thethyrotropin (TSH) receptor and intracellular accumulation ofcyclic AMP. High AGP concentrations, however, inhibited TSH signalling.[5][6]

Alpha-1-acid glycoprotein has been identified as one of four potentially useful circulating biomarkers for estimating the five-year risk of all-cause mortality (the other three arealbumin,very low-density lipoprotein particle size, andcitrate).[7]

Orosomucoid increases in amount in obstructivejaundice while it diminishes in hepatocellular jaundice and inintestinalinfections.[citation needed]

See also

[edit]

References

[edit]
  1. ^Logan, Carolynn M.; Rice, M. Katherine (1987).Logan's Medical and Scientific Abbreviations. Philadelphia:J. B. Lippincott Company. p. 3.ISBN 0-397-54589-4.
  2. ^abcColombo S, Buclin T, Décosterd LA, Telenti A, Furrer H, Lee BL, Biollaz J, Eap CB (October 2006). "Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation".Clinical Pharmacology and Therapeutics.80 (4):307–18.doi:10.1016/j.clpt.2006.06.006.PMID 17015049.S2CID 684478.
  3. ^Urien S, Brée F, Testa B, Tillement JP (November 1991)."pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid)".The Biochemical Journal. 280 ( Pt 1) (1):277–80.doi:10.1042/bj2800277.PMC 1130632.PMID 1741754.
  4. ^Rooke GA (2009). "Anesthesia for the Older Patient". In Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC (eds.).Clinical Anesthesia. Lippincott Williams & Wilkins. p. 879.ISBN 978-0-7817-8763-5.
  5. ^Zimmermann-Belsing T, Rasmussen AK, Feldt-Rasmussen U, Bøg-Hansen TC (February 2002). "The influence of alpha1-acid glycoprotein (orosomucoid) and its glycoforms on the function of human thyrocytes and CHO cells transfected with the human TSH receptor".Molecular and Cellular Endocrinology.188 (1–2):241–51.doi:10.1016/s0303-7207(01)00650-5.PMID 11911961.S2CID 22815279.
  6. ^Dietrich JW, Landgrafe G, Fotiadou EH (2012)."TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis".Journal of Thyroid Research.2012: 351864.doi:10.1155/2012/351864.PMC 3544290.PMID 23365787.
  7. ^Fischer K, Kettunen J, Würtz P, Haller T, Havulinna AS, Kangas AJ, Soininen P, Esko T, Tammesoo ML, Mägi R, Smit S, Palotie A, Ripatti S, Salomaa V, Ala-Korpela M, Perola M, Metspalu A (February 2014)."Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons".PLOS Medicine.11 (2): e1001606.doi:10.1371/journal.pmed.1001606.PMC 3934819.PMID 24586121.

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