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| Clinical data | |
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| Other names | Dimethylhexylamine; DMHA; Ottodrina; Vaporpac; Amidrine; 2-Aminoisooctane;2-aminoisoheptane; 2-Amino-6-methylheptane; 1,5-Dimethylhexylamine; 6-Methyl-2-heptylamine; 6-Methyl-2-heptanamine; Isoctaminium; SKF-51; SK&F-51; NSC-759813[1] |
| Routes of administration | Oral, inhaled |
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| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Metabolism | Hydroxylation[3] |
| Metabolites | Heptaminol[3] |
| Identifiers | |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.008.047 |
| Chemical and physical data | |
| Formula | C8H19N |
| Molar mass | 129.247 g·mol−1 |
| 3D model (JSmol) | |
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Octodrine, also known asdimethylhexylamine (DMHA) and sold under the brand nameVaporpac among others, is asympathomimetic andstimulantmedication that was formerly used in the treatment ofhypotension (low blood pressure).[4][5]
It has been studied in a dozenanimal studies from the 1940s through the 1970s. These studies found that octodrine can increaseblood pressure andcardiac output in animals. The drug was previously approved for use by theFood and Drug Administration (FDA) as aninhalant (i.e.,Vaporpac andTickle Tackle Inhaler) and inGermany as anoralmedication as part of amulti-component medication (i.e.,Ambredin andOrdinal), but is no longer available.[6]
DMHA has also been found as anadulterant in sports supplements and is sold online as adesigner drug.[6][7] The presence of a reductive amination byproduct confirms its synthetic origin.[8]
In the United States, the FDA considers DMHA to be an unsafe ingredient indietary supplements.[9]In 2019, the FDA issued ninewarning letters to US manufacturers of dietary supplements containing DMHA as an unsafe food additive, deeming such products to be adulterated and illegal for marketing.[10]
Reportedside effects of octodrine includehypertension,dyspnea, andhyperthermia.[5]
It is described as asympathomimetic,vasoconstrictor, andlocal anesthetic.[5][11]
Heptaminol is anactive metabolite of octodrine.[3]
Octodrine is thegeneric name of the drug and itsINNTooltip International Nonproprietary Name andUSANTooltip United States Adopted Name.[11][4] It is also known by its former developmental code nameSKF-51.[11]
In the United States, DMHA is not eligible for use as a dietary ingredient, is not approved for use in manufactured foods or dietary supplements, and is not considered to be safe for human consumption (is notGRAS); in regarding DMHA as an unsafe food additive, the FDA has warned manufacturers that dietary supplements containing DMHA are adulterated and illegal for marketing.[9][10]
