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OR8B8

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
OR8B8
Identifiers
AliasesOR8B8, TPCR85, olfactory receptor family 8 subfamily B member 8
External IDsMGI:2177528;HomoloGene:56568;GeneCards:OR8B8;OMA:OR8B8 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR8B8
Genomic location for OR8B8
Band11q24.2Start124,437,445bp[1]
End124,445,696bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for OR8B8
Genomic location for OR8B8
Band9|9 A4Start37,808,020bp[2]
End37,814,815bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • atrium

  • right auricle of heart
Top expressed in
  • epithelium

  • body proper

  • organ system

  • sensory nervous system

  • respiratory epithelium

  • sensory organ

  • structure with developmental contribution from neural crest

  • nasal epithelium

  • peripheral nervous system

  • olfactory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26493

258310

Ensembl

ENSG00000197125

ENSMUSG00000066748

UniProt

Q15620

Q60882

RefSeq (mRNA)

NM_012378

NM_146313

RefSeq (protein)

NP_036510

NP_666425

Location (UCSC)Chr 11: 124.44 – 124.45 MbChr 9: 37.81 – 37.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 8B8 is aprotein that in humans is encoded by theOR8B8gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000197125Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000066748Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (Apr 1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species".Genomics.39 (3):239–46.doi:10.1006/geno.1996.4490.PMID 9119360.
  6. ^ab"Entrez Gene: OR8B8 olfactory receptor, family 8, subfamily B, member 8".

Further reading

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External links

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This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.


Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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