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OR2K2

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens
OR2K2
Identifiers
AliasesOR2K2, HSHTPCRH06, HTPCRH06, OR2AN1P, OR2AR1P, olfactory receptor family 2 subfamily K member 2
External IDsMGI:3030101;HomoloGene:17436;GeneCards:OR2K2;OMA:OR2K2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for OR2K2
Genomic location for OR2K2
Band9q31.3Start111,327,229bp[1]
End111,330,224bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for OR2K2
Genomic location for OR2K2
Band4|4 B3Start58,782,704bp[2]
End58,787,716bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • C1 segment

  • substantia nigra

  • gastrocnemius muscle

  • tibial nerve

  • hippocampus proper

  • Hypothalamus

  • muscle of thigh

  • primary visual cortex

  • putamen
Top expressed in
  • embryo

  • uterus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26248

258922

Ensembl

ENSG00000171133

ENSMUSG00000043385

UniProt

Q8NGT1

A2AM35

RefSeq (mRNA)

NM_205859

NM_146920

RefSeq (protein)

NP_995581

NP_667131

Location (UCSC)Chr 9: 111.33 – 111.33 MbChr 4: 58.78 – 58.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2K2 is aprotein that in humans is encoded by theOR2K2gene.[5][6][7]

Olfactory receptors interact with odorant molecules in thenose, to initiate a neuronal response that triggers the perception of asmell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[7]

See also

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References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000171133Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000043385Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells".Nature.355 (6359):453–5.Bibcode:1992Natur.355..453P.doi:10.1038/355453a0.PMID 1370859.S2CID 43926.
  6. ^Aloni R, Olender T, Lancet D (Jan 2007)."Ancient genomic architecture for mammalian olfactory receptor clusters".Genome Biol.7 (10): R88.doi:10.1186/gb-2006-7-10-r88.PMC 1794568.PMID 17010214.
  7. ^ab"Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2".

Further reading

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External links

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This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.


Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13
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