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OR2B6

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
OR2B6
Identifiers
AliasesOR2B6, OR2B1, OR2B1P, OR2B5, OR2B6P, OR5-40, OR5-41, OR6-31, dJ408B20.2, olfactory receptor family 2 subfamily B member 6
External IDsMGI:104715;HomoloGene:40838;GeneCards:OR2B6;OMA:OR2B6 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for OR2B6
Genomic location for OR2B6
Band6p22.1Start27,957,241bp[1]
End27,958,182bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for OR2B6
Genomic location for OR2B6
Band13 A3.1|13 7.9 cMStart21,820,793bp[2]
End21,826,688bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • monocyte

  • gonad

  • blood

  • granulocyte

  • right lobe of liver

  • placenta

  • spleen

  • Ventricular system of neuraxis

  • embryo
Top expressed in
  • white adipose tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26212

218066

Ensembl

ENSG00000124657

ENSMUSG00000036658

UniProt

P58173

Q60890

RefSeq (mRNA)

NM_012367

NM_146542

RefSeq (protein)

NP_036499

NP_666753

Location (UCSC)Chr 6: 27.96 – 27.96 MbChr 13: 21.82 – 21.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2B6 is aprotein that in humans is encoded by theOR2B6gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000124657Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000036658Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome".Nat Genet.18 (3):243–50.doi:10.1038/ng0398-243.PMID 9500546.S2CID 31129045.
  6. ^ab"Entrez Gene: OR2B6 olfactory receptor, family 2, subfamily B, member 6".

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.


Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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