Olfactory receptor 1D2 is aprotein that in humans is encoded by theOR1D2gene.[4][5][6]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[6]
As well as bring expressed in theolfactory epithelium of the human nose, OR1D2 is special in that it is also expressed in humanspermatozoa, where it is involved in sperm chemotaxis.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells".Nature.355 (6359):453–5.Bibcode:1992Natur.355..453P.doi:10.1038/355453a0.PMID1370859.S2CID43926.
Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J (1992). "Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences".Brain Res. Mol. Brain Res.13 (1–2):159–63.doi:10.1016/0169-328X(92)90057-I.PMID1315913.
Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire".Hum. Mol. Genet.3 (2):229–35.doi:10.1093/hmg/3.2.229.PMID8004088.
Schurmans S, Muscatelli F, Miot F, et al. (1993). "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13→p12 region of the human genome and reveals an MspI restriction fragment length polymorphism".Cytogenet. Cell Genet.63 (3):200–4.doi:10.1159/000133534.PMID8097991.
Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster".Genomics.63 (2):227–45.doi:10.1006/geno.1999.6030.PMID10673334.S2CID23416814.
