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OR1B1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
OR1B1
Identifiers
AliasesOR1B1, OR9-26, OR9-B, olfactory receptor family 1 subfamily B member 1 (gene/pseudogene), olfactory receptor family 1 subfamily B member 1
External IDsMGI:3030196;HomoloGene:17479;GeneCards:OR1B1;OMA:OR1B1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for OR1B1
Genomic location for OR1B1
Band9q33.2Start122,628,579bp[1]
End122,629,573bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for OR1B1
Genomic location for OR1B1
Band2|2 BStart36,991,718bp[2]
End37,007,922bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • endometrium

  • cervix

  • lymph node

  • right lung

  • gallbladder

  • superior frontal gyrus

  • canal of the cervix
Top expressed in
  • spermatid

  • testicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

347169

259053

Ensembl

ENSG00000280094

ENSMUSG00000075377

UniProt

Q8NGR6

Q8VGV7

RefSeq (mRNA)

NM_001004450

NM_147051

RefSeq (protein)

NP_001004450

NP_667262

Location (UCSC)Chr 9: 122.63 – 122.63 MbChr 2: 36.99 – 37.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1B1 is aprotein that in humans is encoded by theOR1B1gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

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As of 2024, OR1B1 was anorphan receptor, meaning that no odorants have been identified which bind to it.[6][7]

See also

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References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000280094Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000075377Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ab"Entrez Gene: OR1B1 olfactory receptor, family 1, subfamily B, member 1".
  6. ^de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era".Flavour and Fragrance Journal.30 (5):342–361.doi:10.1002/ffj.3249.
  7. ^"OR1B1".M2OR. ChemSenSim lab, Université Côte d’Azur, Institut de Chimie de Nice. 2024-03-23. Retrieved2024-07-04.

Further reading

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External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.


Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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