Olfactory receptor 1A1 is aprotein that in humans is encoded by theOR1A1gene.[5][6]
Olfactory receptors interact withodorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family ofG-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter andhormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.[6]
OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules.[7][8]Examples of known ligands, most of which have citrus or fruity smells:[9][10]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster".Genomics.63 (2):227–45.doi:10.1006/geno.1999.6030.PMID10673334.S2CID23416814.
^abcSchmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2".Journal of Structural Biology.159 (3):400–12.doi:10.1016/j.jsb.2007.04.013.PMID17601748.
