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O-1656

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
O-1656
Clinical data
ATC code
  • none
Identifiers
  • 2-cycloheptyl-5-(2-methyloctan-2-yl)benzene-1,3-diol
CAS Number
PubChemCID
Chemical and physical data
FormulaC22H36O2
Molar mass332.528 g·mol−1
3D model (JSmol)
  • CCCCCCC(C)(C)C1=CC(=C(C(=C1)O)C2CCCCCC2)O
  • InChI=1S/C22H36O2/c1-4-5-6-11-14-22(2,3)18-15-19(23)21(20(24)16-18)17-12-9-7-8-10-13-17/h15-17,23-24H,4-14H2,1-3H3
  • Key:AECZEBWFCJESSN-UHFFFAOYSA-N

O-1656 is acannabinoid agonist which was invented by Billy R Martin and Raj K Razdan atOrganix Inc in 2002. It is moderately selective for theCB2 receptor with aCB1 receptor affinity of 18 nM and a CB2 receptor affinity of 2 nM.[1][2][3] Since it has acycloheptyl ring attached to thephenol core, it falls outside the definition of a"cyclohexylphenol derivative", but may still be controlled by generic legislation in some jurisdictions.

See also

[edit]

References

[edit]
  1. ^WO application 03091189, Martin BR, Razdan RK, "Cannabinoids", published 6 November 2003, assigned to University of Virginia 
  2. ^Wiley JL, Beletskaya ID, Ng EW, Dai Z, Crocker PJ, Mahadevan A, Razdan RK, Martin BR (May 2002). "Resorcinol derivatives: a novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists".The Journal of Pharmacology and Experimental Therapeutics.301 (2):679–89.doi:10.1124/jpet.301.2.679.PMID 11961073.S2CID 12741224.
  3. ^Adam J, Cowley PM, Kiyoi T, Morrison AJ, Mort CJ (2006). "Recent progress in cannabinoid research".Progress in Medicinal Chemistry.44:207–329.doi:10.1016/S0079-6468(05)44406-9.ISBN 9780444517371.PMID 16697899.
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