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O-1238

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
O-1238
Identifiers
  • (6aR)-3-[(Z)-6-Azidohex-2-enyl]-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number
PubChemCID
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H29N3O2
Molar mass367.493 g·mol−1
3D model (JSmol)
  • CC3=CCC2C(C)(C)Oc(c1C2C3)cc(cc1O)CC=CCCCN=N=N
  • InChI=1S/C22H29N3O2/c1-15-9-10-18-17(12-15)21-19(26)13-16(14-20(21)27-22(18,2)3)8-6-4-5-7-11-24-25-23/h4,6,9,13-14,17-18,26H,5,7-8,10-12H2,1-3H3/b6-4-/t17?,18-/m1/s1
  • Key:WCIOISWISHFTFW-UWFURQARSA-N
  (verify)

O-1238 is a drug which is acannabinoid derivative that is used in scientific research. It is a partialagonist at the cannabinoidreceptorCB1,[1] producing a maximal stimulation of 58.3%[2] with aKi of 8.45 nM.[3]

References

[edit]
  1. ^Griffin G, Wray EJ, Martin BR, Abood ME (October 1999)."Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum".British Journal of Pharmacology.128 (3):684–8.doi:10.1038/sj.bjp.0702806.PMC 1571656.PMID 10516649.
  2. ^Griffin G, Wray EJ, Rorrer WK, Crocker PJ, Ryan WJ, Saha B, et al. (April 1999)."An investigation into the structural determinants of cannabinoid receptor ligand efficacy".British Journal of Pharmacology.126 (7):1575–84.doi:10.1038/sj.bjp.0702469.PMC 1565939.PMID 10323589.
  3. ^Ross RA, Gibson TM, Stevenson LA, Saha B, Crocker P, Razdan RK, Pertwee RG (October 1999)."Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors".British Journal of Pharmacology.128 (3):735–43.doi:10.1038/sj.bjp.0702836.PMC 1571677.PMID 10516656.
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