The neurogenic locus notch homolog 4 protein is a member of theNotch family. Members of thistype 1 transmembrane protein family share structural characteristics. These include an extracellular domain consisting of multipleepidermal growth factor-like (EGF)repeats, and an intracellular domain that consists of multiple, but different, domain types.
Notch protein family members play a role in a variety of developmental processes by controlling cell fate decisions. TheNotch signaling pathway is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells
InDrosophila,notch interacts with its cell-bound ligands (delta and serrate), and establishes an intercellular signaling pathway that then plays a key role in development. Homologues of thenotch-ligands have also been identified in humans, but precise interactions between these ligands and the humannotch homologues remain to be determined. Thenotch protein is cleaved in thetrans-Golgi network, and then presented on the cell surface as aheterodimer. The protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal, and hepatic development.[6]
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