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| Other names | Norfenephrine; Norphenephrine; Norphenylephrine;meta-Norsynephrine;meta-Octopamine; 3-Octopamine; Adrianol; 3,β-Dihydroxyphenethylamine; 3,β-Dihydroxy-β-phenylethylamine |
| AHFS/Drugs.com | International Drug Names |
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| Pharmacokinetic data | |
| Metabolism | m-Hydroxymandelic acid[1][2] |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.007.844 |
| Chemical and physical data | |
| Formula | C8H11NO2 |
| Molar mass | 153.181 g·mol−1 |
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Norfenefrine, also known asmeta-octopamine ornorphenylephrine and sold under the brand nameNovadral among others, is asympathomimeticmedication which is used in the treatment ofhypotension (low blood pressure).[3][4][5][6] Along with itsstructural isomerp-octopamine and thetyramines, norfenefrine is anaturally occurringendogenoustrace amine and plays a role as a minorneurotransmitter in thebrain.[7]
Norfenefrine is used in the treatment ofhypotension (low blood pressure).[3] It is said to be similarly effective or less effective thanmidodrine.[8][9][10]
Norfenefrine is described as anα-adrenergic receptoragonist andsympathomimetic agent.[4][6] It is said to act predominantly as anα1-adrenergic receptor agonist.[3]
Norfenefrine, also known as 3,β-dihydroxyphenethylamine, is asubstituted phenethylaminederivative.[4][6] It is ananalogue ofnorepinephrine (3,4,β-trihydroxyphenethylamine), ofmeta-tyramine (3-hydroxyphenethylamine), ofphenylephrine ((R)-β,3-dihydroxy-N-methylphenethylamine), ofetilefrine (3,β-dihydroxy-N-ethylphenethylamine), and ofmetaterol (3,β-dihydroxy-N-isopropylphenethylamine), as well as ofmetaraminol ((1R,2S)-3,β-dihydroxy-α-methylphenethylamine).[4]
Norfenefrine is used medically as thehydrochloridesalt.[4][6]
The predictedlog P of norfenefrine is -0.28 to -0.95.[11][12][13]
Norfenefrine is thegeneric name of the drug and itsINNTooltip International Nonproprietary Name.[4][6] Synonyms of norfenefrine includehydroxyphenylethanolamine,nor-phenylephrine, andm-norsynephrine, among others.[4][6] Brand names of norfenefrine includeNovadral,A.S. COR,Coritat,Energona,Hypolind,Norfenefrin Ziethen, andNorfenefrin-Ratiopharm, among others.[6]
Norfenefrine is marketed inEurope,Japan, andMexico.[6]