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| Clinical data | |
|---|---|
| Trade names | Axid, Tazac |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a694030 |
| License data | |
| Pregnancy category |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | >70% |
| Protein binding | 35% |
| Metabolism | Liver |
| Eliminationhalf-life | 1–2 hours |
| Excretion | Kidney |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| IUPHAR/BPS | |
| DrugBank |
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| ChemSpider |
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| UNII | |
| KEGG |
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| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.155.683 |
| Chemical and physical data | |
| Formula | C12H21N5O2S2 |
| Molar mass | 331.45 g·mol−1 |
| 3D model (JSmol) | |
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Nizatidine is a histamineH2 receptor antagonist that inhibitsstomach acid production, and is commonly used in the treatment ofpeptic ulcer disease andgastroesophageal reflux disease.[2]
It was patented in 1980 and approved for medical use in 1988.[3][4] It was developed byEli Lilly.
Nizatidine is used to treatduodenal ulcers,gastric ulcers, andgastroesophageal reflux disease (GERD/GORD), and to preventstress ulcers.[5]
Side effects are uncommon, usually minor, and include diarrhea, constipation, fatigue, drowsiness, headache, and muscle aches.[5]
Nizatidine was developed byEli Lilly, and was first marketed in 1988.[3] It is considered to be equipotent withranitidine and differs by the substitution of athiazole ring in place of thefuran ring in ranitidine. In September 2000, Eli Lilly announced they would sell the sales and marketing rights for Axid toReliant Pharmaceuticals.[6] Subsequently, Reliant developed the oral solution of Axid, marketing this in 2004, after gaining approval from theU.S. Food and Drug Administration (FDA).[7] However, a year later, they sold rights of the Axid Oral Solution (including the issued patent[8] protecting the product) toBraintree Laboratories.[9]
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Brand names include Tazac and Axid.
