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Nipecotic acid

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Nipecotic acid
Identifiers
  • Piperidine-3-carboxylic acid
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.007.159Edit this at Wikidata
Chemical and physical data
FormulaC6H11NO2
Molar mass129.159 g·mol−1
3D model (JSmol)
  • C1CC(CNC1)C(=O)O

Nipecotic acid is aGABA reuptake inhibitor used inscientific research.[1][2][3] It has very little to noblood–brain barrierpenetration itself, butstructural modifications have been made to improve this.[4][5]

See also

[edit]

References

[edit]
  1. ^Macdonald RL (2012). Eadie MJ, Vajda FJ (eds.).Antiepileptic drugs: pharmacology and therapeutics (First ed.). [S.l.]: Springer. p. 130.ISBN 978-3-642-64244-9.In contrast, prolonged (1 h) exposure to gabapentin enhanced the shunting effect on CAl region excitatory postsynaptic potentials induced by the GABA uptake inhibitor, nipecotic acid, which promotes GABA release.
  2. ^Takahashi K, Miyoshi S, Kaneko A, Copenhagen DR (1995)."Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina".The Japanese Journal of Physiology.45 (3):457–473.doi:10.2170/jjphysiol.45.457.PMID 7474528.
  3. ^Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures".Epilepsy Research.86 (2–3):113–123.doi:10.1016/j.eplepsyres.2009.05.008.PMID 19535226.S2CID 32999271.
  4. ^Shek E (1994). "Chemical delivery systems and prodrugs of anticonvulsive drugs".Advanced Drug Delivery Reviews.14 (2–3):227–241.doi:10.1016/0169-409X(94)90041-8.Nipecotic acid is a potent in vitro inhibitor of neuronal and glial GABA uptake. However, because nipecotic acid does not penetrate the blood-brain barrier (BBB) it lacks any in vivo activity [23,24].
  5. ^Dhanawat M, Gupta S, Mehta DK, Das R (February 2021). "Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug".Drug Research.71 (2):94–103.doi:10.1055/a-1290-0119.PMID 33241549.
GABATooltip γ-Aminobutyric acidmetabolism andtransportmodulators
Transporter
GATTooltip GABA transporter
VIAATTooltip Vesicular inhibitory amino acid transporter
Enzyme
GADTooltip Glutamate decarboxylase
GABA-TTooltip γ-Aminobutyrate aminotransferase
Other
Antivitamin B6
Receptor
(ligands)
GlyRTooltip Glycine receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Transporter
(blockers)
GlyT1Tooltip Glycine transporter 1
GlyT2Tooltip Glycine transporter 2
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