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Niflumic acid

From Wikipedia, the free encyclopedia
Drug used in treatment of joint and muscular pain
Pharmaceutical compound
Niflumic acid
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
Eliminationhalf-life2.5 hr[1]
Identifiers
  • 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.022.289Edit this at Wikidata
Chemical and physical data
FormulaC13H9F3N2O2
Molar mass282.222 g·mol−1
3D model (JSmol)
Melting point204 °C (399 °F)
  • C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
  • InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) ☒N
  • Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor ofcyclooxygenase-2. In experimental biology, it has been employed to inhibitchloride channels.[2] It has also been reported to act on GABA-A[3] andNMDA channels[4] and to block T-type calcium channels.[5]

References

[edit]
  1. ^"Half life".Drug Bank. Retrieved15 July 2011.
  2. ^Knauf PA, Mann NA (May 1984)."Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system".The Journal of General Physiology.83 (5):703–25.doi:10.1085/jgp.83.5.703.PMC 2215658.PMID 6736917.
  3. ^Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug".Molecular Pharmacology.64 (3):753–63.doi:10.1124/mol.64.3.753.PMID 12920213.
  4. ^Lerma J, Martín del Río R (February 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation".Molecular Pharmacology.41 (2):217–22.doi:10.1016/S0026-895X(25)08859-5.PMID 1371581.
  5. ^Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (June 2012)."Niflumic acid blocks native and recombinant T-type channels".Journal of Cellular Physiology.227 (6):2542–55.doi:10.1002/jcp.22992.PMC 4146346.PMID 21898399.
pyrazolones /
pyrazolidines
salicylates
acetic acid derivatives
and related substances
oxicams
propionic acid
derivatives (profens)
n-arylanthranilic
acids (fenamates)
COX-2 inhibitors
(coxibs)
other
NSAID
combinations
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;withdrawn drugs;veterinary use.
Topical products forjoint andmuscular pain (M02)
Anti-inflammatory
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non-steroids
Pyrazolidines
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Calcium
VDCCsTooltip Voltage-dependent calcium channels
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Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
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IRKsTooltip Inwardly rectifying potassium channel
Blockers
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KCaTooltip Calcium-activated potassium channel
Blockers
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K2PsTooltip Tandem pore domain potassium channel
Blockers
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Sodium
VGSCsTooltip Voltage-gated sodium channels
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ENaCTooltip Epithelial sodium channel
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ASICsTooltip Acid-sensing ion channel
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CaCCsTooltip Calcium-activated chloride channel
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator
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KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
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EP (E2)Tooltip Prostaglandin E2 receptor
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PGD2STooltip Prostaglandin D synthase
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TXASTooltip Thromboxane A synthase
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