Distinguished for his original and varied contributions to mammalian developmental genetics, genome organisation and gene expression. His early work established the abundance ofmessenger RNAs during mouse development, and led to the cloning of several genes that are expressed specifically in the liver. Further studies of theserpin gene family uncovered the first clear example of "accelerated protein evolution". At this time he also identified several novel repetitive elements in the mousegenome. His group was the first to characterise mammaliantelomeres, and to demonstrate telomere shortening with age in man. Nick Hastie's current work is focused on human developmental mutations, notablyWilm's tumour andAniridia. His group demonstrated that aniridia, and the mouse equivalent, smalleye, are caused by mutations in thePAX6 gene. He continues to make incisive contributions to our understanding of the role ofWT1, the candidate Wilm's Tumour gene, in development of thekidney andgonad.[13]
^"HASTIE, Prof. Nicholas Dixon Anne".Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.(subscription required)
^Teslovich, T. M.; Musunuru, K.; Smith, A. V.; Edmondson, A. C.; Stylianou, I. M.; Koseki, M.; Pirruccello, J. P.; Ripatti, S.; Chasman, D. I.; Willer, C. J.; Johansen, C. T.; Fouchier, S. W.; Isaacs, A.; Peloso, G. M.; Barbalic, M.; Ricketts, S. L.; Bis, J. C.; Aulchenko, Y. S.; Thorleifsson, G.; Feitosa, M. F.; Chambers, J.; Orho-Melander, M.; Melander, O.; Johnson, T.; Li, X.; Guo, X.; Li, M.; Shin Cho, Y.; Jin Go, M.; et al. (2010)."Biological, clinical and population relevance of 95 loci for blood lipids".Nature.466 (7307):707–13.Bibcode:2010Natur.466..707T.doi:10.1038/nature09270.PMC3039276.PMID20686565.
