Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Neurotrophin-4

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
NTF4
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1HCF,1B8M,1B98

Identifiers
AliasesNTF4, GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5, neurotrophin 4
External IDsOMIM:162662;MGI:97381;HomoloGene:4503;GeneCards:NTF4;OMA:NTF4 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NTF4
Genomic location for NTF4
Band19q13.33Start49,061,066bp[1]
End49,065,076bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for NTF4
Genomic location for NTF4
Band7 B3|7 29.3 cMStart45,063,119bp[2]
End45,066,603bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • skeletal muscle tissue

  • skin of abdomen

  • muscle of thigh

  • skin of leg

  • gonad

  • prostate

  • mucosa of esophagus

  • gastrocnemius muscle

  • minor salivary glands
Top expressed in
  • hand

  • Gonadal ridge

  • molar

  • sternocleidomastoid muscle

  • tibialis anterior muscle

  • upper arm

  • knee joint

  • triceps brachii muscle

  • urothelium

  • vas deferens
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4909

78405

Ensembl

ENSG00000225950

ENSMUSG00000074121

UniProt

P34130

Q80VU4

RefSeq (mRNA)

NM_006179
NM_001395489

NM_198190

RefSeq (protein)

NP_006170

NP_937833

Location (UCSC)Chr 19: 49.06 – 49.07 MbChr 7: 45.06 – 45.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurotrophin-4 (NT-4),[5] also known asneurotrophin-5 (NT-5), is aprotein that in humans is encoded by theNTF4gene.[6] It is aneurotrophic factor that signals predominantly through theTrkBreceptor tyrosine kinase.[7][8] NT-4 was first discovered and isolated fromxenopus andviper in the year 1991 by Finn Hallbooket.al[9]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000225950Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000074121Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Ibáñez CF, Ernfors P, Timmusk T, Ip NY, Arenas E, Yancopoulos GD, Persson H (April 1993). "Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion".Development.117 (4):1345–1353.doi:10.1242/dev.117.4.1345.PMID 8404536.
  6. ^"Entrez Gene: neurotrophin 4".
  7. ^Klein R, Lamballe F, Bryant S, Barbacid M (May 1992). "The trkB tyrosine protein kinase is a receptor for neurotrophin-4".Neuron.8 (5):947–956.doi:10.1016/0896-6273(92)90209-v.PMID 1375038.S2CID 9772551.
  8. ^Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, et al. (February 1993). "Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells".Neuron.10 (2):137–149.doi:10.1016/0896-6273(93)90306-c.PMID 7679912.S2CID 46072027.
  9. ^Hallböök F, Ibáñez CF, Persson H (May 1991). "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary".Neuron.6 (5):845–858.doi:10.1016/0896-6273(91)90180-8.PMID 2025430.S2CID 17772282.

Further reading

[edit]

External links

[edit]
PDB gallery
  • 1b98: NEUROTROPHIN 4 (HOMODIMER)
    1b98: NEUROTROPHIN 4 (HOMODIMER)
  • 1b8m: BRAIN DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-4
    1b8m: BRAIN DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-4
  • 1hcf: CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5
    1hcf: CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5
Neurotrophins
GDNF family
Ephrins
CNTF family
Other
Angiopoietin
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
IGF-2
Others
LNGF (p75NTR)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
SCF (c-Kit)
TGFβ
Trk
TrkA
TrkB
TrkC
VEGF
Others
Stub icon

This article on agene on humanchromosome 19 is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Neurotrophin-4&oldid=1311576454"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp