The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system.[7] Binding and pharmacological studies demonstrate that this receptor bindsNeurotensin (NT) as well as several other ligands already described forNeurotensin receptor 1. NT function is known to be aneuromodulator of dopamine and hashypothermic andanalgesic properties in the brain and some peripheral organ function as well.[8] NTS2 is found mostly in the brain through Northern-blot analysis.[8]Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.[8]
^Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, et al. (November 1998). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells".European Journal of Pharmacology.360 (2–3):265–272.doi:10.1016/S0014-2999(98)00678-5.PMID9851594.
Vincent JP, Mazella J, Kitabgi P (July 1999). "Neurotensin and neurotensin receptors".Trends in Pharmacological Sciences.20 (7):302–309.doi:10.1016/S0165-6147(99)01357-7.PMID10390649.
Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, et al. (June 2002). "Expression of neurotensin receptors in human corneal keratocytes".Investigative Ophthalmology & Visual Science.43 (6):1765–1771.PMID12036977.
Leyton J, Garcia-Marin L, Jensen RT, Moody TW (May 2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells".European Journal of Pharmacology.442 (3):179–186.doi:10.1016/S0014-2999(02)01539-X.PMID12065070.
Somaï S, Gompel A, Rostène W, Forgez P (July 2002). "Neurotensin counteracts apoptosis in breast cancer cells".Biochemical and Biophysical Research Communications.295 (2):482–488.doi:10.1016/S0006-291X(02)00703-9.PMID12150975.
"Neurotensin Receptors: NTS2".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-05.
