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Neuropeptide FF receptor 2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

NPFFR2

Identifiers

Aliases

NPFFR2, GPR74, HLWAR77, NPFF2, NPGPR, neuropeptide FF receptor 2

External IDs

OMIM:607449;MGI:1860130;HomoloGene:56982;GeneCards:NPFFR2;OMA:NPFFR2 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.3	Start	72,031,902bp^[1]
Band	4q13.3	End	72,148,305bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 E1	Start	89,675,288bp^[2]
Band	5\|5 E1	End	89,731,599bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

testicle

placenta

islet of Langerhans

prefrontal cortex

parietal pleura

gastric mucosa

seminal vesicula

Brodmann area 9

appendix

Top expressed in

primary oocyte

zygote

secondary oocyte

embryo

spinal ganglia

blastocyst

olfactory bulb

mandibular prominence

testicle

trigeminal ganglion

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	opioid receptor binding peptide binding G protein-coupled receptor activity signal transducer activity neuropeptide receptor activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane actin cytoskeleton
Biological process	G protein-coupled receptor signaling pathway detection of abiotic stimulus cellular response to hormone stimulus regulation of MAPK cascade regulation of adenylate cyclase activity regulation of cAMP-dependent protein kinase activity signal transduction response to peptide neuropeptide signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


10886


104443

Ensembl


ENSG00000056291


ENSMUSG00000035528

UniProt


Q9Y5X5


Q924H0

RefSeq (mRNA)


NM_001144756 NM_004885 NM_053036


NM_133192

RefSeq (protein)


NP_001138228 NP_004876 NP_444264


NP_573455

Location (UCSC)

Chr 4: 72.03 – 72.15 Mb

Chr 5: 89.68 – 89.73 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neuropeptide FF receptor 2, also known asNPFF2 and formerly asGPR74, is a humanprotein encoded by theNPFFR2gene.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000056291 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000035528 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: NPFFR2 neuropeptide FF receptor 2".

External links

[edit]

"Neuropeptide FF Receptors: NPFF2".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-09.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)