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| Clinical data | |
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| Trade names | Alocril |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601243 |
| Routes of administration | Inhalation andeye drops |
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| Pharmacokinetic data | |
| Protein binding | 89% |
| Metabolism | not metabolized |
| Eliminationhalf-life | ~3.3 hours |
| Excretion | excreted unchanged |
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| ECHA InfoCard | 100.233.208 |
| Chemical and physical data | |
| Formula | C19H17NO7 |
| Molar mass | 371.345 g·mol−1 |
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Nedocromil sodium is amedication considered amast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused byasthma. It is administered by aninhaler under the brand nameTilade, and as aneye drop under the brand nameAlocril.[1][2] The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators likealbuterol or other well-knowninhaler medications. Liquid preparations of nedocromil are available in theUK under the nameRapitil for use for allergic eye reactions.[3] Nedocromil sodium has been shown to be effective in alleviating symptoms ofallergic conjunctivitis.[4]
Nedocromil is classified as abenzopyrone. Nedocromil acts as amast cell stabilizer, inhibits the degranulation ofmast cells, prevents release ofhistamine andtryptase, so preventing the synthesis ofprostaglandins andleukotrienes. US Production of inhaled nedocromil ceased in April 2008 because it usedCFCs as propellant.[5]
Media related toNedocromil at Wikimedia Commons
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