| Comité consultatif national de l'immunisation | |
| Agency overview | |
|---|---|
| Formed | 1964 (1964) |
| Jurisdiction | Government of Canada |
| Headquarters | Ottawa,Ontario |
| Minister responsible | |
| Agency executives |
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| Parent agency | Public Health Agency of Canada |
| Website | https://www.canada.ca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci.html |
TheNational Advisory Committee on Immunization (NACI;French:Comité consultatif national de l'immunisation;CCNI) is anadvisory body that provides theGovernment of Canada with medical and scientific advice relating to humanimmunization.[1]
The NACI's precursor, The National Advisory Committee on Immunizing Agents, was established in 1964. And it was mandated to provide advice on immunizing agents to theDepartment of National Health and Welfare. In 1975, focus on advice related to the introduction of new vaccines and to assist in the development of immunization programs became the new mandate of the committee. In 1978, the committee was officially renamed into The National Advisory Committee on Immunization, in order to reflect the new mandate for consideration of procedures related to immunization and immunization coverage.[2]
NACI is mandated to provide thePublic Health Agency of Canada (PHAC) with medical, scientific, and public health advice relating to vaccines, including the use of vaccines in humans, vaccine evaluation, and the monitoring ofvaccine-associated adverse events.[3]
The NACI is composed of 14 voting members (chair, vice-chair, and 12 voting members), executive secretary, roughly a dozen industry liaison representatives, and roughly a dozen ex-officio professionalpublic service representatives fromHealth Canada. NACI's voting members composed of experts in the fields of immunization, public health, vaccine preventable diseases, pediatric or adult infectious diseases, allergy/immunology, other health related fields.[3][4]
As of May 2024[update], the membership of NACI consists of:[4]
NACI became prominent during theCOVID-19 pandemic, as publisher of recommendations and guidance surrounding distribution ofCOVID-19 vaccines.[1][5] Some of NACI's recommendations have been criticized as counter-productive in terms of public health and communications concerning the pandemic.[6]
In March 2021, amid supply shortages, NACI issued a strong recommendation that second doses of two-dose COVID-19 vaccines (such as theAstraZeneca,Moderna, andPfizer vaccines) be given up to four months after the first, as opposed to the three-to-four week intervals used in the clinical trials and recommended by Health Canada. NACI stated that this recommendation was based on modelling from data showing that "the first two months of real world effectiveness are showing sustained high levels of protection."[6]
Pfizer Canada president Cole Pinnow warned against the recommendation in theHouse of Commons, stating that "the data that we’ve seen from a real world evidence perspective that has been used to make arguments to extend the dose schedule has been done on much younger populations", and that "we don't have any data after two months to know what the impact of one dose will be."[7]
On May 28, citing improved vaccine availability, NACI recommended that second doses be administered "as soon as possible", and especially to individuals who are at high risk, but that it "continues to recommend that jurisdictions should maximize the number of individuals benefiting from the first dose of a COVID-19 vaccine by extending the second dose of COVID-19 vaccine up to four months after the first."[8][9]
On May 4, 2021, NACI issued a recommendation thatmRNA-based vaccines should be preferred overviral vector vaccines such as the AstraZeneca andJanssen vaccines, due to the rare risk ofvaccine-induced immune thrombotic thrombocytopenia (VITT). Vice-chairmanShelley Deeks stated that "individuals need to have an informed choice to be vaccinated with the first vaccine that's available, or to wait for an mRNA vaccine."[10]
Various politicians and public health authorities argued that such statements concerning officially-approved vaccines would encouragehesitancy, and impede the public health goal of inoculating the public as quickly as possible.[10] On May 6, NACI issued a follow-up statement wishing to clarify that their previous statement was not to imply that anyone taking a vaccine such as AstraZeneca was making a mistake, and that it was adequately effective for protecting againstCOVID-19.[11]
On 1 June 2021, NACI issued a recommendation that those who had received the AstraZeneca vaccine as their first dose may safely receive an mRNA vaccine as their second dose instead. The recommendation cited studies occurring in Europe over similar mixing of doses being performed due to concerns over the AstraZeneca vaccine, including one that showed a sevenfold increase in antibody presence in patients who received AstraZeneca as their first dose and Pfizer as their second. It is still recommended that those who received an mRNA vaccine as a first dose receive the same vaccine for their second dose, but that the two mRNA vaccines can be interchangeable if supply is limited.[12]
Public health officials warned that Canada's use and orders of the AstraZeneca had to be controlled in order to prevent waste, especially as those concerned over VITT (which was associated more with the first dose) request an mRNA option for their second dose instead.[13]
Some countries and non-Canadian businesses have refused to recognize individuals that have received mixed doses as being fully vaccinated; at U.S.-based ports, multiple cruise lines stated that they would only accept passengers fully vaccinated in means approved by theUS FDA (only accepting matching doses of the Moderna or Pfizer vaccine, or the Janssen vaccine). In mid-July, Prime MinisterJustin Trudeau stated that they were "going to work with the international community to make sure that people who are fully vaccinated in ways that Canadians recognize as safe and effective are also recognized around the world."[14][15][16]
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