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Naltriben

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Naltriben
Clinical data


ATC code	none
Identifiers
CAS Number	111555-58-9^Y
PubChemCID	5486827
IUPHAR/BPS	1640
ChemSpider	4589081^Y
UNII	RXG719F189
ChEMBL	ChEMBL100940^Y
PDB ligand	ZY8 (PDBe,RCSB PDB)
CompTox Dashboard(EPA)	DTXSID80912218
Chemical and physical data
Formula	C₂₆H₂₅NO₄
Molar mass	415.489 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7
InChI InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1^Y Key:ZHVWWEYETMPAMX-IFKAHUTRSA-N^Y
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Naltriben is a potent and selectiveantagonist for thedelta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonistnaltrindole, but with different binding affinity for the δ₁ and δ₂ subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.^[1] It also acts as aκ-opioid agonist at high doses.^[2]

References

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^Sofuoglu M, Portoghese PS, Takemori AE (May 1991). "Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes".The Journal of Pharmacology and Experimental Therapeutics.257 (2):676–80.doi:10.1016/S0022-3565(25)24699-7.PMID 1851833.
^Stewart PE, Holper EM, Hammond DL (1994). "Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes".Life Sciences.55 (4): PL79-84.doi:10.1016/0024-3205(94)00738-1.PMID 8028443.