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Nafadotride

From Wikipedia, the free encyclopedia
Nervous system drug
Nafadotride
Names
IUPAC name
N-{[(2S)-1-butylpyrrolidin-2-yl]methyl}-4-cyano-1-methoxy-2-naphthamide
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
MeSHNafadotride
UNII
  • InChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26)
    Key: IDZASIQMRGPBCQ-UHFFFAOYSA-N
  • CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC
Properties
C22H27N3O2
Molar mass365.477 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound

Nafadotride is adopamine antagonist with someselectivity for theD3 subtype (9.6-fold preference for D3 over D2).[1]

See also

[edit]

References

[edit]
  1. ^Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 agonist.Nature. 1999;400:371–375.
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
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