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Nadrian Seeman

From Wikipedia, the free encyclopedia
American physicist (1945–2021)
Nadrian C. Seeman
Seeman in 2002
Born(1945-12-16)December 16, 1945
DiedNovember 16, 2021(2021-11-16) (aged 75)
Alma materUniversity of Chicago, University of Pittsburgh
Known forDNA nanotechnology
AwardsKavli Prize in Nanoscience(2010)
William H. Nichols Medal(2008)
Benjamin Franklin Medal in Chemistry(2016)
Scientific career
FieldsNanotechnology, Crystallography
InstitutionsNew York University
Doctoral studentsHao Yan

Nadrian C. "Ned" Seeman (December 16, 1945 – November 16, 2021) was an Americannanotechnologist andcrystallographer known for inventing the field ofDNA nanotechnology.[1][2][3]

Biography

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Seeman studied biochemistry at theUniversity of Chicago and crystallography at theUniversity of Pittsburgh.[4] He was a postdoctoral researcher withAlexander Rich atMIT. He became a faculty member at theState University of New York at Albany, and in 1988 moved to the Department of Chemistry atNew York University.

He is most noted for his development of the concept ofDNA nanotechnology beginning in the early 1980s.[1] In fall 1980, while at a campus pub, Seeman was inspired by theM. C. Escher woodcutDepth to realize that a three-dimensional lattice could be constructed from DNA. He realized that this could be used to orient target molecules, simplifying their crystallographic study by eliminating the difficult process of obtaining pure crystals.[5][6] In pursuit of this goal, Seeman's laboratory published the synthesis of the first three-dimensional nanoscale object, a cube made of DNA, in 1991. This work won the 1995Feynman Prize in Nanotechnology.[7] The concept of the dissimilar doubleDNA crossover introduced by Seeman,[8] was important stepping stone towards the development ofDNA origami. The goal of demonstrating designed three-dimensional DNA crystals was achieved by Seeman in 2009, nearly thirty years after his original elucidation of the idea.

The concepts of DNA nanotechnology later found further applications inDNA computing,[9]DNA nanorobotics, andself-assembly ofnanoelectronics.[10] He shared theKavli Prize in Nanoscience 2010 withDonald Eigler “for their development of unprecedented methods to control matter on the nanoscale.”[10][11] He was a fellow of theNorwegian Academy of Science and Letters.[12]

He was an atheist.[13] Seeman died on November 16, 2021, at the age of 75.[14]

Notable publications

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See also

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References

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  1. ^abPelesko, John A. (2007).Self-assembly: the science of things that put themselves together. New York: Chapman & Hall/CRC. pp. 201, 242, 259.ISBN 978-1-58488-687-7.
  2. ^Dennis Overbye (3 June 2010)."8 Scientists Share $3 Million in Prizes".The New York Times.
  3. ^"NYU Chemistry Remembers Ned Seeman 1945-2021".New York University. Retrieved2021-11-18.
  4. ^"Ned's Biography". Nadrian Seeman lab.
  5. ^Seeman, Nadrian C. (June 2004)."Nanotechnology and the double helix".Scientific American.290 (6):64–75.Bibcode:2004SciAm.290f..64S.doi:10.1038/scientificamerican0604-64.PMID 15195395.
  6. ^See Nadrian Seeman's homepage,Current crystallization protocol for a statement of the problem, and Nadrian Seeman's homepage,DNA cages containing oriented guests for the proposed solution.
  7. ^"1995 Feynman Prize in Nanotechnology Awarded For Pioneering Synthesis of 3-D DNA Objects". The Foresight Institute. 30 November 1995. Archived fromthe original on 26 July 2012. Retrieved4 June 2010.
  8. ^Fu, Tsu-Ju; Seeman, Nadrian (1993). "DNA Double-Crossover Molecules".Biochemistry.32 (13):3211–3220.doi:10.1021/bi00064a003.PMID 8461289.
  9. ^Ng, W. D.; Wong, C. K. B. (2007)."Self-Recognition of DNA: From Life Processes to DNA Computation".Biophysical Reviews and Letters.2 (2):123–137.doi:10.1142/S1793048007000490.PMC 2905173.PMID 20640192.
  10. ^ab"NYU Chemist Seeman Wins Kavli Prize in Nanoscience". New York University. 3 June 2010.
  11. ^"Names of the 2010 Kavli Prize winners announced". The Kavli Prize. Archived fromthe original on 2012-06-28. Retrieved2010-06-04.
  12. ^"Gruppe 4: Kjemi" (in Norwegian). Norwegian Academy of Science and Letters. Archived fromthe original on 3 March 2012. Retrieved30 March 2016.
  13. ^"Nadrian C. Seeman life story".www.kavliprize.org. Retrieved2022-06-05.
  14. ^NYU Chemistry Remembers Ned Seeman 1945–2021
  15. ^Pinheiro, A. V.; Han, D.; Shih, W. M.; Yan, H. (December 2011)."Challenges and opportunities for structural DNA nanotechnology".Nature Nanotechnology.6 (12):763–772.Bibcode:2011NatNa...6..763P.doi:10.1038/nnano.2011.187.PMC 3334823.PMID 22056726.

External links

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