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Nadoxolol

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Nadoxolol
Names

IUPAC name N′,3-Dihydroxy-4-naphthalen-1-yloxybutanimidamide
Identifiers
CAS Number	54063-51-3^Y 35991-93-6 (hydrochloride)^Y
3D model (JSmol)	Interactive image
ChemSpider	4886543
EC Number	252-825-2
MeSH	C006154
PubChem CID	6328253
UNII	SK43HU1689^Y RZ9G589EN2^Y
CompTox Dashboard(EPA)	DTXSID90968903
InChI InChI=1S/C14H16N2O3/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,17-18H,8-9H2,(H2,15,16) Key: UPZVYDSBLFNMLK-UHFFFAOYSA-N InChI=1/C14H16N2O3/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,17-18H,8-9H2,(H2,15,16) Key: UPZVYDSBLFNMLK-UHFFFAOYAW
SMILES C1=CC=C2C(=C1)C=CC=C2OCC(C/C(=N/O)/N)O
Properties
Chemical formula	C₁₄H₁₆N₂O₃
Molar mass	260.293 g·mol⁻¹
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

Nadoxolol is anantiarrhythmic agent (i.e., a drug for the treatment of irregular heartbeat),^[1] chemically related in structure tobeta-adrenergic receptor blocker drugs such aspropranolol.^[2]

It does not appear to be marketed anywhere in the world.

^Warembourg, H; Ducloux, G (1976). "Clinical study of a new anti-arrhythmia agent: nadoxolol".Lille Med.21 (4):386–8.PMID 957857.
^Kapoor, M; Anand, N; Koul, S; Chimni, SS; Manhas, KS; Raina, C; Parshad, R; Taneja, SC; Qazi, GN (2003). "Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers".Bioorganic Chemistry.31 (3):259–69.doi:10.1016/s0045-2068(03)00050-6.PMID 12818235.

Agonists

Antagonists

Agonists

Antagonists

Agonists

Antagonists

class Ia (Phase 0→ andPhase 3→)	Ajmaline Disopyramide Hydroquinidine Lorajmine Prajmaline Procainamide^# Quinidine^# Sparteine
class Ib (Phase 3←)	IV Lidocaine^# enteral Aprindine Mexiletine Tocainide
class Ic (Phase 0→)	Encainide^‡ Ethacizine Flecainide Indecainide^‡ Lorcainide Moracizine^‡ Propafenone

class II (Phase 4→,β blockers)	Nadolol Pindolol Propranolol cardioselective Acebutolol Atenolol Esmolol Landiolol Metoprolol
A₁ agonist	Adenosine Benzodiazepines Barbiturates
M₂	muscarinic antagonist:Atropine Disopyramide Quinidine muscarinic agonist:Digoxin
α receptors	Amiodarone Bretylium Quinidine Verapamil

Na⁺/ K⁺-ATPase	Digitoxin Digoxin Ouabain

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