Homeobox protein Nkx-2.2 is aprotein that in humans is encoded by theNKX2-2gene.[5][6][7]
Homeobox protein Nkx-2.2 contains ahomeobox domain and may be involved in themorphogenesis of the central nervous system. This gene is found on chromosome 20 nearNKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form ofTITF1 andNKX2-8. The encoded protein is likely to be a nucleartranscription factor.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Aug 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese".Diabetes.47 (8):1356–1358.doi:10.2337/diabetes.47.8.1356.PMID9703340.
^Price M, Lazzaro D, Pohl T, Mattei MG, Rüther U, Olivo JC, Duboule D, Di Lauro R (Feb 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain".Neuron.8 (2):241–255.doi:10.1016/0896-6273(92)90291-K.PMID1346742.S2CID22766848.
Hessabi B, Schmidt I, Walther R (Apr 2000). "The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals".Biochemical and Biophysical Research Communications.270 (3):695–700.doi:10.1006/bbrc.2000.2491.PMID10772886.
Wang CC, Brodnicki T, Copeland NG, Jenkins NA, Harvey RP (Jun 2000). "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals".Mammalian Genome.11 (6):466–468.doi:10.1007/s003350010089.PMID10818213.S2CID29283599.
