The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus uponT cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression ofcytokine genes in T cells, especially in the induction of theIL-2 andIL-4.[6]
Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function".Annual Review of Immunology.15:707–47.doi:10.1146/annurev.immunol.15.1.707.PMID9143705.
Jabado N, Le Deist F, Fisher A, Hivroz C (Nov 1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity".European Journal of Immunology.24 (11):2646–52.doi:10.1002/eji.1830241112.PMID7957556.S2CID30435577.
Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A (Nov 1994). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif".Biochemical and Biophysical Research Communications.205 (1):467–74.Bibcode:1994BBRC..205..467V.doi:10.1006/bbrc.1994.2689.PMID7999066.
Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT (Sep 1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering".European Journal of Immunology.26 (9):2181–8.doi:10.1002/eji.1830260933.PMID8814265.S2CID23430217.
Lahti AL, Manninen A, Saksela K (May 2003). "Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB".Virology.310 (1):190–6.doi:10.1016/S0042-6822(03)00164-8.PMID12788643.
