This gene encodes a member of theneuroD family of neurogenicbasic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as theGAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells inXenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively".Genomics.40 (2):355–7.doi:10.1006/geno.1996.4578.PMID9119405.
Kume H, Maruyama K, Shinozaki K, Kuzume H, Obata K (Sep 1998). "Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein".Brain Research. Molecular Brain Research.60 (1):107–14.doi:10.1016/S0169-328X(98)00176-4.PMID9748526.
Kitamura T, Miyachi T, Nakamura S, Kawakami H (Apr 1999). "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1445 (1):142–7.doi:10.1016/s0167-4781(99)00038-x.PMID10209266.
Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2".Brain Research. Molecular Brain Research.74 (1–2):126–34.doi:10.1016/S0169-328X(99)00273-9.PMID10640683.
Cousin P, Billotte J, Chaubert P, Shaw P (Jan 2000). "Physical map of 17p13 and the genes adjacent to p53".Genomics.63 (1):60–8.doi:10.1006/geno.1999.6062.PMID10662545.
Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain".Journal of Child Neurology.16 (11):849–53.doi:10.1177/08830738010160111201.PMID11732772.S2CID20069074.
Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB (Apr 2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion".Mechanisms of Development.113 (1):85–90.doi:10.1016/S0925-4773(01)00665-7.PMID11900979.S2CID11607202.
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Zill P, Büttner A, Eisenmenger W, Bondy B (Jun 2006). "A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior".Molecular Psychiatry.11 (6):525–7.doi:10.1038/sj.mp.4001825.PMID16607387.S2CID7713810.
