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NCAPD3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

NCAPD3

Identifiers

Aliases

NCAPD3, CAP-D3, CAPD3, hCAP-D3, hHCP-6, hcp-6, non-SMC condensin II complex subunit D3, MCPH22

External IDs

OMIM:609276;MGI:2142989;HomoloGene:41021;GeneCards:NCAPD3;OMA:NCAPD3 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q25	Start	134,150,113bp^[1]
Band	11q25	End	134,225,504bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A4	Start	26,941,471bp^[2]
Band	9\|9 A4	End	27,006,611bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

secondary oocyte

ventricular zone

gonad

prostate

ganglionic eminence

testicle

stromal cell of endometrium

right lobe of liver

left testis

Top expressed in

hand

Gonadal ridge

Paneth cell

primary oocyte

thymus

dermis

human fetus

superior cervical ganglion

neural layer of retina

abdominal wall

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	methylated histone binding chromatin binding protein binding histone binding
Cellular component	membrane nucleus condensed chromosome, centromeric region nucleoplasm
Biological process	mitotic chromosome condensation chromosome separation cell division cell cycle chromosome condensation meiotic chromosome condensation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


23310


78658

Ensembl


ENSG00000151503


ENSMUSG00000035024

UniProt


P42695


Q6ZQK0

RefSeq (mRNA)


NM_015261 NM_001372065 NM_001372068 NM_001372069 NM_001372070


NM_178113 NM_001382847

RefSeq (protein)


NP_056076 NP_001358994 NP_001358997 NP_001358998 NP_001358999


NP_835214 NP_001369776

Location (UCSC)

Chr 11: 134.15 – 134.23 Mb

Chr 9: 26.94 – 27.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Condensin-2 complex subunit D3 (CAP-D3) also known asnon-SMC condensin II complex subunit D3 (NCAPD3) is aprotein that, in humans, is encoded by theNCAPD3gene.^[5]^[6]^[7]^[8] CAP-D3 is a subunit ofcondensin II, a large protein complex involved in chromosome condensation.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000151503 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000035024 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (December 1995)."Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1".DNA Research.1 (5):223–229.doi:10.1093/dnares/1.5.223.PMID 7584044.
^Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (June 1996). "A "double adaptor" method for improved shotgun library construction".Analytical Biochemistry.236 (1):107–113.doi:10.1006/abio.1996.0138.PMID 8619474.
^Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T (October 2003)."Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells".Cell.115 (1):109–121.doi:10.1016/S0092-8674(03)00724-4.PMID 14532007.S2CID 18811084.
^"NCAPD3 non-SMC condensin II complex, subunit D3".National Center for Biotechnology Information. RetrievedJune 10, 2012.

Yu W, Andersson B, Worley KC, et al. (1997)."Large-scale concatenation cDNA sequencing".Genome Res.7 (4):353–8.doi:10.1101/gr.7.4.353.PMC 139146.PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proc. Natl. Acad. Sci. U.S.A.101 (33):12130–5.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC 514446.PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics".Nature.433 (7021):77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID 15635413.S2CID 4344740.
Nousiainen M, Silljé HH, Sauer G, et al. (2006)."Phosphoproteome analysis of the human mitotic spindle".Proc. Natl. Acad. Sci. U.S.A.103 (14):5391–6.Bibcode:2006PNAS..103.5391N.doi:10.1073/pnas.0507066103.PMC 1459365.PMID 16565220.

Structures of thecell nucleus /nuclear protein

Envelope (membrane)/
nuclear lamina

Nucleolus

Other

Chromatin Dot (PML body) Paraspeckle
SMC protein:	Cohesin SMC1A SMC1B SMC3 Condensin NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 SMC2 SMC4 DNA repair SMC5 SMC6
Transition nuclear protein:	TNP1 TNP2
Nuclear matrix (Nucleoskeleton) Nucleoplasm (Nucleosol)
LITAF
see alsotranscription factors and intracellular receptors

see alsonucleus diseases

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