| NAD+-diphthamide ADP-ribosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.2.36 | ||||||||
| CAS no. | 52933-21-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, aNAD+-diphthamide ADP-ribosyltransferase (EC2.4.2.36) is anenzyme thatcatalyzes thechemical reaction
Thus, the twosubstrates of this enzyme areNAD+ and peptidediphthamide, whereas its twoproducts arenicotinamide and peptideN-(ADP-D-ribosyl)diphthamide.
This enzyme belongs to the family ofglycosyltransferases, to be specific, the pentosyltransferases. Thesystematic name of this enzyme class isNAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase. Other names in common use includeADP-ribosyltransferase,mono(ADPribosyl)transferase, andNAD-diphthamide ADP-ribosyltransferase.
As of late 2007, 15structures have been solved for this class of enzymes, withPDB accession codes1S5B,1S5C,1S5D,1S5E,1S5F,1SGK,1TOX,1XDT,1XK9,1ZM3,1ZM4,1ZM9,2A5D,2A5F, and2A5G.
The extracellular ADP-ribosyl-transferase ART2 isexpressed only onT cells.[1] T cell activation ofP2X7 receptors can activate the T cells or cause T cell differentiation, can affect T cell migration or (at high extracellular levels of NAD+) can induce cell death by ART2.[1]
