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| ECHA InfoCard | 100.020.031 |
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| Formula | C20H23NO3 |
| Molar mass | 325.408 g·mol−1 |
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N-Methyl-3-piperidyl benzilate (JB-336 orLBJ) is ananticholinergic drug related to thechemical warfare agent3-quinuclidinyl benzilate.
N-methyl-3-piperidyl benzilate is less potent and shorter acting than 3-quinuclidyl benzilate, but like 3-QNB its effects on the central nervous system predominate over peripheral effects. It producesdeliriant andhallucinogenic effects similar to those of plants such asdatura and may be used recreationally at low doses; however, unpleasant side effects such asdysphoria,nausea and vomiting,dizziness and extremedry mouth tend to make abuse of drugs of this kind uncommon. Both the N-methyl and N-ethyl analogues of 3-piperidyl benzilate are, however,Schedule I controlled drugs.
Radiolabelled versions of this drug are used in scientific research to map the distribution ofmuscarinicacetylcholine receptors in the brain.[1]
Reaction of JB-336 withmethyl bromide gives the gastrointestinal drugMepenzolate bromide.
