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| Other names | Diformylmescaline;N,N-Diformyl-3,4,5-trimethoxyphenethylamine;N,N-Diformyl-3,4,5-TMPEA |
| Drug class | Serotonergic psychedelic;Hallucinogen |
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| Chemical and physical data | |
| Formula | C13H17NO5 |
| Molar mass | 267.281 g·mol−1 |
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N,N-Diformylmescaline, also known asN,N-diformyl-3,4,5-trimethoxyphenethylamine, is a possiblepsychedelic drug of thephenethylamine andscaline families related tomescaline.[1][2][3] It is theN,N-diformylderivative of mescaline.[1][2][3] The compound has been found to bechemically unstable underacidic orbasic conditions, breaking down intoN-formylmescaline and then into mescaline.[1][2][3] Relatedly, it is thought thatN,N-diformylmescaline may act as aprodrug of mescalinein vivo.[1][2][3] Thechemical synthesis of the compound has been described.[2][3] It was encountered as a possible noveldesigner drug in 2020 and this was reported in 2022.[1][2][3]N,N-Diformylmescaline itself is not known to benaturally occurring, butN-formylmescaline is known to occur naturally in trace amounts inpeyote.[2][3][4][5][6]
In January 2020, Australian authorities seized a powder suspected of being cocaine. After analysis by GC–MS, NMR and IR, the compound was identified as N,N-diformylmescaline. Under exposure to acid and basic conditions, the structure degraded to N-formylmescaline, a naturally occurring compound in Peyote, and further to mescaline (Gallagher et al., 2023).
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