Themyxobacteria ("slime bacteria") are a group ofbacteria that predominantly live in the soil and feed on insoluble organic substances. The myxobacteria have very largegenomes relative to other bacteria, e.g. 9–10 millionnucleotides except forAnaeromyxobacter[2] andVulgatibacter.[3] One species of myxobacteria,Minicystis rosea,[4] has the largest known bacterial genome with over 16 million nucleotides. The second largest is another myxobacteriaSorangium cellulosum.[5][6]
Myxobacteria can move bygliding.[7] They typically travel inswarms (also known aswolf packs), containing manycells kept together by intercellular molecularsignals. Individuals benefit from aggregation as it allows accumulation of the extracellularenzymes that are used to digest food; this in turn increases feeding efficiency. Myxobacteria produce a number of biomedically and industrially useful chemicals, such asantibiotics, and export those chemicals outside the cell.[8]
Myxobacteria are used to study the polysaccharide production in gram-negative bacteria like the modelMyxococcus xanthus which have four different mechanisms[9] of polysaccharide secretion and where a new Wzx/Wzy mechanism producing a newpolysaccharide was identified in 2020.[9]
When nutrients are scarce, myxobacterial cells aggregate intofruiting bodies (not to be confused withthose in fungi), a process long-thought to be mediated bychemotaxis but now considered to be a function of a form of contact-mediated signaling.[11][12] These fruiting bodies can take different shapes and colors, depending on the species. Within the fruiting bodies, cells begin as rod-shaped vegetative cells, and develop into rounded myxospores with thick cell walls. These myxospores, analogous tospores in other organisms, are more likely to survive until nutrients are more plentiful. The fruiting process is thought to benefit myxobacteria by ensuring thatcell growth is resumed with a group (swarm) of myxobacteria, rather than as isolated cells. Similar life cycles have developed among certainamoebae, called cellularslime molds.
Various myxobacterial species as sketched by Roland Thaxter in 1892:Chondromyces crocatus (figs. 1–11),Stigmatella aurantiaca (figs. 12–19 and 25-28),Melittangium lichenicola (figs. 20–23),Archangium gephyra (fig. 24),Myxococcus coralloides (figs. 29-33),Polyangium vitellinum (figs. 34-36), andMyxococcus fulvus (figs. 37-41). Thaxter was the first taxonomist to recognize the bacterial nature of the myxobacteria. Previously, they had been misclassified as members of thefungi imperfecti.[15]
It has been suggested that the last common ancestor of myxobacteria was an aerobe and that their anaerobic predecessors lived syntrophically with early eukaryotes.[16]
^Subramanian, S.; Sharma, G. (19 August 2015) [Submitted on 15 August 2015]."Vulgatibacter incomptus strain DSM 27710, complete genome".Nucleotide. National Library of Medicine, National Center for Biotechnology Information. GenBank ID CP012332.1. Retrieved8 October 2024.
