Spiteri Debono was born Miriam Zammit inVictoria,Gozo, to Pawlu Zammit and his wife.[5] Spiteri is a typicalSicilian surname.[6] She received her formal childhood education in Gozo and later attended theUniversity of Malta where she studied English Literature and Linguistics, graduating in 1973, and founded the Socialist Students Union.[7][8] She also studied law and graduated as aNotary Public in 1980.[9][7]
Her first public office appointments included that of chair of the Cooperatives Board, and as a founding member of the Gender Equality Commission.[9]
She was a candidate for theMalta Labour Party in five general elections (1981, 1987, 1992, 1996, 2003), but was never elected as a member of parliament.[10][11] However, she was elected to the party's national executive in 1982 and served as the party's propaganda secretary.[7][12]
Spiteri Debono served as president of theMalta Labour Party's women section between 1993 and 1996.[13][14]
In January 2023, she was proposed for the role of Standards Commissioner by theNationalist Party, however, she declined to be formally considered for the role claiming that she was not suited for it nor was she interested in taking the position.[15]
On 21 March 2024, she was reported to be the front runner to be appointedPresident of the Republic of Malta.[16][17] The following week, this was confirmed in a joint statement issued from the offices of the Prime Minister and the Leader of the Opposition.[18] Malta's House of Representatives voted unanimously toelect Spiteri Debono as Malta's 11th President on 27 March 2024, becoming the first president to be elected using the new constitutional reforms of 2020 including the new requirement of two-thirds of the parliament's approval for the presidential nominee.[9]
At the time of her appointment she admitted to being atechnophobe; owning aflip phone and preferring to dictate her letters and other correspondence to an assistant, leaving emails to an email address in her husband's name.[21]
Spiteri Debono lived most of her adult life inBirkirkara, Malta.[14] She was married to notary Dr. Anthony Spiteri Debono, who died on 24 July 2025, at the age of 78.[22] They have three children and four grandchildren.[23]