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Moxastine

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Chemical compound

Pharmaceutical compound

Moxastine
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	none
Identifiers
IUPAC name 2-[1,1-di(phenyl)ethoxy]-N,N-dimethylethanamine
CAS Number	3572-74-5^Y
PubChemCID	19142
ChemSpider	18062^N
UNII	ZSJ254W6SF
CompTox Dashboard(EPA)	DTXSID60189244
ECHA InfoCard	100.020.626
Chemical and physical data
Formula	C₁₈H₂₃NO
Molar mass	269.388 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN(C)C
InChI InChI=1S/C18H23NO/c1-18(20-15-14-19(2)3,16-10-6-4-7-11-16)17-12-8-5-9-13-17/h4-13H,14-15H2,1-3H3^N Key:BBIMHFSPNXQFAH-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Moxastine (also known asmephenhydramine) is anantihistamine andanticholinergic.^[1]

It was developed in Czechoslovakia^[2] and sold in hydrochloride form as an antihistamine (Alfadryl).

It is, with8-chlorotheophylline, a component of cocrystal/saltmoxastine teoclate (mephenhydrinate) used as antiemetic (Theadryl; Kinedryl (with caffeine)).

References

[edit]

^Saxena AK, Saxena M (1992). "Developments in antihistamines (H1)". In Jucker E (ed.).Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. pp. 35–125.doi:10.1007/978-3-0348-7144-0_3.ISBN 978-3-0348-7146-4.
^Wardell WM (1978).Controlling the Use of Therapeutic Drugs An International Comparison. Washington, D.C.: American Enterprise Institute for Public Policy Research. p. 242.ISBN 978-0-8447-3278-7.

Agonists	Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49
Antagonists	Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine

H₃

Agonists	α-Methylhistamine BP 2.94 Cipralisant (GT-2331) GT-2203 (VUF-5296) Histamine Imetit Immepip Immethridine (BP-1-5375) L-Histidine Methimepip Proxyfan SCH-50971 VUF-5297
Antagonists	A-349821 A-423579 ABT-239 ABT-652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK-189254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681

H₄

Agonists	4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430
Antagonists	JNJ-7777120 Mianserin Seliforant Thioperamide Toreforant VUF-6002

See also: Receptor/signaling modulators; Monoamine metabolism modulators; Monoamine reuptake inhibitors

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